Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …
postponement of disease, preservation of function, and increased stress resistance. Whether …
Lithocholic acid phenocopies anti-ageing effects of calorie restriction
Q Qu, Y Chen, Y Wang, S Long, W Wang, HY Yang… - Nature, 2024 - nature.com
Calorie restriction (CR) is a dietary intervention used to promote health and longevity,. CR
causes various metabolic changes in both the production and the circulation of metabolites; …
causes various metabolic changes in both the production and the circulation of metabolites; …
Caloric restriction, Sirtuins, and cardiovascular diseases
Z Wei, B Yang, H Wang, S Lv, H Chen… - Chinese Medical …, 2024 - mednexus.org
Caloric restriction (CR) is a well-established dietary intervention known to extend healthy
lifespan and exert positive effects on aging-related diseases, including cardiovascular …
lifespan and exert positive effects on aging-related diseases, including cardiovascular …
[HTML][HTML] NAD+: An Old but Promising Therapeutic Agent for Skeletal Muscle Ageing
Y Xu, W **ao - Ageing Research Reviews, 2023 - Elsevier
More than a century after the discovery of nicotinamide adenine dinucleotide (NAD+), our
understanding of the molecule's role in the biology of ageing continues to evolve. As a …
understanding of the molecule's role in the biology of ageing continues to evolve. As a …
The effects of graded levels of calorie restriction: XIX. Impact of graded calorie restriction on protein expression in the liver
Calorie restriction (CR) extends life span by modulating the mechanisms involved in aging.
We quantified the hepatic proteome of male C57BL/6 mice exposed to graded levels of CR …
We quantified the hepatic proteome of male C57BL/6 mice exposed to graded levels of CR …
[HTML][HTML] Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing
Q Qu, Y Chen, Y Wang, W Wang, S Long, HY Yang… - Nature, 2024 - nature.com
Lithocholic acid (LCA) is accumulated in mammals during calorie restriction and it can
activate AMP-activated protein kinase (AMPK) to slow down ageing. However, the molecular …
activate AMP-activated protein kinase (AMPK) to slow down ageing. However, the molecular …
Impact of caloric restriction on oxidative stress and key glycolytic enzymes in the cerebral cortex, liver and kidney of old and middle-aged mice
Caloric restriction (CR) is proposed as a strategy to prevent age-related alterations like
impaired glucose metabolism and intensification of oxidative stress. In this study, we …
impaired glucose metabolism and intensification of oxidative stress. In this study, we …
The Effects of Graded Levels of Calorie Restriction XXI: impact of short term graded restriction on gene expression profiles of stomach and skeletal muscle
F **a, Y Wu, M Li, SE Mitchell… - The Journals of …, 2024 - academic.oup.com
Calorie restriction (CR) extends lifespan and prevents several aging related diseases.
During short-term restriction, we previously showed that lean tissues generally decrease in …
During short-term restriction, we previously showed that lean tissues generally decrease in …
The effects of graded levels of calorie restriction: XX. Impact of long-term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice
Calorie restriction (CR) typically promotes a reduction in body mass, which correlates with
increased lifespan. We evaluated the overall changes in survival, body mass dynamics, and …
increased lifespan. We evaluated the overall changes in survival, body mass dynamics, and …
Independent and combined effects of calorie restriction and AICAR on glucose uptake and insulin signaling in skeletal muscles from 24-month-old female and male …
We assessed the effects of two levels of calorie restriction (CR; eating either 15% or 35%
less than ad libitum, AL, food intake for 8 weeks) by 24-month-old female and male rats on …
less than ad libitum, AL, food intake for 8 weeks) by 24-month-old female and male rats on …