Hypocretin/orexin neurons are distributed restrictively in the hypothalamus, a brain region
known to orchestrate diverse functions including sleep, reward processing, food intake …

In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self‐
administration with the intermittent access (IntA) procedure produces a robust addiction‐like …

Background The prevalence of eating disorders, including binge eating disorder, is
significantly higher in women. These findings are mirrored by preclinical studies, which …

Reducing sleep hours is a risk factor for develo** cardiovascular, metabolic, and
psychiatric disorders. Furthermore, previous studies have shown that reduction in sleep time …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …

The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays
an important role in drug addiction. However, neural circuits underlying LH involvement of …

As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD)
treatments could not be more urgent. Two separate hypothalamic neuropeptide systems …

The neuropeptide hypocretin/orexin plays a broad and important role in physiological
functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and …

Obesity and other eating disorders are marked by dysregulations to brain metabolic,
hedonic, motivational, and sensory systems that control food intake. Classic approaches in …