Microglia are specialized brain-resident macrophages that arise from primitive macrophages
colonizing the embryonic brain. Microglia contribute to multiple aspects of brain …

Despite the tremendous success, pitfalls have been observed in every step of a clinical
metabolomics workflow, which impedes the internal validity of the study. Furthermore, the …

Western-type diets are linked to obesity and diabetes partly because of their high–saturated
fatty acid (SFA) content. We found that SFAs, but not unsaturated fatty acids (USFAs) …

Quantitative MS of human plasma lipids is a promising technology for translation into clinical
applications. Current MS-based lipidomic methods rely on either direct infusion (DI) or …

Background Red blood cell (RBC) storage promotes biochemical and morphological
alterations, collectively referred to as storage lesions (SLs). Studies in humans have …

Introduction The effect of medium-chain fatty acid-containing triglycerides (MCT), long-chain
polyunsaturated fatty acid-containing triglycerides from fish oil (FO), and their combination …

Technological advances in high-resolution mass spectrometry (MS) vastly increased the
number of samples that can be processed in a life science experiment, as well as volume …

Background In infant bronchiolitis, recent evidence indicates that respiratory viruses (eg,
respiratory syncytial virus [RSV], rhinovirus [RV]) contribute to the heterogeneity of disease …

Lipidomic approaches are widely used to investigate the relationship between lipids, human
health, and disease. Conventional sample preparation techniques for the extraction of lipids …

Florida manatees (Trichechus manatus latirostris), a federally protected species, are
classified as threatened due to anthropogenic stressors. Manatees inhabit sites that are …