Physical models of collective cell migration

R Alert, X Trepat - Annual Review of Condensed Matter Physics, 2020 - annualreviews.org
Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Motility-induced phase separation

ME Cates, J Tailleur - Annu. Rev. Condens. Matter Phys., 2015 - annualreviews.org
Self-propelled particles include both self-phoretic synthetic colloids and various
microorganisms. By continually consuming energy, they bypass the laws of equilibrium …

Motility-driven glass and jamming transitions in biological tissues

D Bi, X Yang, MC Marchetti, ML Manning - Physical Review X, 2016 - APS
Cell motion inside dense tissues governs many biological processes, including embryonic
development and cancer metastasis, and recent experiments suggest that these tissues …

Emergent behavior in active colloids

A Zöttl, H Stark - Journal of Physics: Condensed Matter, 2016 - iopscience.iop.org
Active colloids are microscopic particles, which self-propel through viscous fluids by
converting energy extracted from their environment into directed motion. We first explain …

Unjamming and cell shape in the asthmatic airway epithelium

JA Park, JH Kim, D Bi, JA Mitchel, NT Qazvini… - Nature materials, 2015 - nature.com
From coffee beans flowing in a chute to cells remodelling in a living tissue, a wide variety of
close-packed collective systems—both inert and living—have the potential to jam. The …

Self-enhanced mobility enables vortex pattern formation in living matter

H Xu, Y Wu - Nature, 2024 - nature.com
Ranging from subcellular organelle biogenesis to embryo development, the formation of self-
organized structures is a hallmark of living systems. Whereas the emergence of ordered …

Active gel physics

J Prost, F Jülicher, JF Joanny - Nature physics, 2015 - nature.com
The mechanical behaviour of cells is largely controlled by a structure that is fundamentally
out of thermodynamic equilibrium: a network of crosslinked filaments subjected to the action …

A density-independent rigidity transition in biological tissues

D Bi, JH Lopez, JM Schwarz, ML Manning - Nature Physics, 2015 - nature.com
Cell migration is important in many biological processes, including embryonic development,
cancer metastasis and wound healing. In these tissues, a cell's motion is often strongly …

Hydrodynamics of soft active matter

MC Marchetti, JF Joanny, S Ramaswamy… - Reviews of modern …, 2013 - APS
This review summarizes theoretical progress in the field of active matter, placing it in the
context of recent experiments. This approach offers a unified framework for the mechanical …

In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition

JA Mitchel, A Das, MJ O'Sullivan, IT Stancil… - Nature …, 2020 - nature.com
The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …