Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …
Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?
R Pluta, S Januszewski, SJ Czuczwar - International Journal of Molecular …, 2021 - mdpi.com
One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …
Heme oxygenases in cardiovascular health and disease
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …
Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model
Cerebral ischemic stroke is one of the leading causes of adult disability worldwide.
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …
Mitochondria‐and Oxidative Stress‐Targeting Substances in Cognitive Decline‐Related Disorders: From Molecular Mechanisms to Clinical Evidence
Alzheimer's disease (AD) is the most common form of dementia affecting people mainly in
their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative …
their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative …
Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1
Ischemic stroke is a debilitating clinical disorder that affects millions of people, yet lacks
effective neuroprotective treatments. Fish oil is known to exert beneficial effects against …
effective neuroprotective treatments. Fish oil is known to exert beneficial effects against …
Ginkgo biloba extract in vascular protection: molecular mechanisms and clinical applications
J Tian, Y Liu, K Chen - Current Vascular Pharmacology, 2017 - ingentaconnect.com
Background: Leaves of Ginkgo biloba, a “living fossil,” have been used as traditional herbal
medicine for hundreds of years in China. Currently, its application in vascular protection is …
medicine for hundreds of years in China. Currently, its application in vascular protection is …
Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety
J Lu, L **e, K Liu, X Zhang, X Wang, X Dai… - Phytotherapy …, 2021 - Wiley Online Library
Bilobalide is a natural sesquiterpene trilactone from Ginkgo biloba leaves. It has good water
solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora …
solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora …
Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage
B Wang, X Zhu, YT Kim, J Li, S Huang, S Saleem… - Free Radical Biology …, 2012 - Elsevier
Interest in histone deacetylase (HDAC)-based therapeutics as a potential treatment for
stroke has grown dramatically. The neuroprotection of HDAC inhibition may involve multiple …
stroke has grown dramatically. The neuroprotection of HDAC inhibition may involve multiple …
Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential
Heat shock proteins (Hsps) are induced by heat shock via heat shock factor proteins binding
to heat shock elements in their promoters. Hsp70 is massively induced in response to …
to heat shock elements in their promoters. Hsp70 is massively induced in response to …