Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches

CD Maida, RL Norrito, M Daidone… - International journal of …, 2020 - mdpi.com
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Neuroinflammation in post-ischemic neurodegeneration of the brain: friend, foe, or both?

R Pluta, S Januszewski, SJ Czuczwar - International Journal of Molecular …, 2021 - mdpi.com
One of the leading causes of neurological mortality, disability, and dementia worldwide is
cerebral ischemia. Among the many pathological phenomena, the immune system plays an …

Heme oxygenases in cardiovascular health and disease

A Ayer, A Zarjou, A Agarwal… - Physiological …, 2016 - journals.physiology.org
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model

AK Rana, R Kumar, DN Shukla, D Singh - Free Radical Biology and …, 2023 - Elsevier
Cerebral ischemic stroke is one of the leading causes of adult disability worldwide.
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …

Mitochondria‐and Oxidative Stress‐Targeting Substances in Cognitive Decline‐Related Disorders: From Molecular Mechanisms to Clinical Evidence

I Lejri, A Agapouda, A Grimm… - Oxidative medicine and …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia affecting people mainly in
their sixth decade of life and at a higher age. It is an extensively studied neurodegenerative …

Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1

M Zhang, S Wang, L Mao, RK Leak, Y Shi… - Journal of …, 2014 - Soc Neuroscience
Ischemic stroke is a debilitating clinical disorder that affects millions of people, yet lacks
effective neuroprotective treatments. Fish oil is known to exert beneficial effects against …

Ginkgo biloba extract in vascular protection: molecular mechanisms and clinical applications

J Tian, Y Liu, K Chen - Current Vascular Pharmacology, 2017 - ingentaconnect.com
Background: Leaves of Ginkgo biloba, a “living fossil,” have been used as traditional herbal
medicine for hundreds of years in China. Currently, its application in vascular protection is …

Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety

J Lu, L **e, K Liu, X Zhang, X Wang, X Dai… - Phytotherapy …, 2021 - Wiley Online Library
Bilobalide is a natural sesquiterpene trilactone from Ginkgo biloba leaves. It has good water
solubility and is widely used in food and pharmaceutical fields. In the last decade, a plethora …

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

B Wang, X Zhu, YT Kim, J Li, S Huang, S Saleem… - Free Radical Biology …, 2012 - Elsevier
Interest in histone deacetylase (HDAC)-based therapeutics as a potential treatment for
stroke has grown dramatically. The neuroprotection of HDAC inhibition may involve multiple …

Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential

FR Sharp, X Zhan, DZ Liu - Translational stroke research, 2013 - Springer
Heat shock proteins (Hsps) are induced by heat shock via heat shock factor proteins binding
to heat shock elements in their promoters. Hsp70 is massively induced in response to …