Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Cell–cell junctions are specializations of the plasma membrane responsible for physically
integrating cells into tissues. We are now beginning to appreciate the diverse impacts that …

To perceive their three-dimensional environment, cells and tissues must be able to sense
and interpret various physical forces like shear, tensile, and compression stress. These …

The linkage of cells to their microenvironment is mediated by a series of bonds that
dynamically engage and disengage, in what has been conceptualized as the molecular …

During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

The cadherin-catenin adhesion complex is the key component of the intercellular adherens
junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial …