Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine
Major depressive disorder (MDD) is a recurrent episodic mood disorder that represents the
third leading cause of disability worldwide. In MDD, several factors can simultaneously …
third leading cause of disability worldwide. In MDD, several factors can simultaneously …
Assessment and management of cognitive and psychosocial dysfunctions in patients with major depressive disorder: A clinical review
A Fiorillo, B Carpiniello, S De Giorgi, S La Pia… - Frontiers in …, 2018 - frontiersin.org
Background: Full functional recovery is defined as a state in which patients are again able to
enjoy their usual activities, return to work, and take care of themselves, and it should …
enjoy their usual activities, return to work, and take care of themselves, and it should …
Changes in symptoms of anhedonia in adults with major depressive or bipolar disorder receiving IV ketamine: Results from the Canadian Rapid Treatment Center of …
Background Anhedonia is a trans-diagnostic, multidimensional phenotype that mediates
patient outcomes and suicidality. Convergent evidence suggests that ketamine may be …
patient outcomes and suicidality. Convergent evidence suggests that ketamine may be …
Personal recovery self-report outcome measures in serious mental illness: A systematic review of measurement properties
S Felix, KM Valery, M Caiada, S Guionnet… - Clinical Psychology …, 2024 - Elsevier
Background Personal recovery represents a paradigm shift in mental healthcare. Validated
self-report outcome measures (PROMs) are needed to facilitate the transformation towards …
self-report outcome measures (PROMs) are needed to facilitate the transformation towards …
Predictors of changes in quality of life of patients with major depressive Disorder—A prospective naturalistic 3-Month Follow-Up study
V Dionisie, MG Puiu, M Manea… - Journal of Clinical …, 2023 - mdpi.com
Major depressive disorder (MDD) is one of the leading causes of disease burden worldwide
and affected patients frequently report impairments in quality of life (QoL). Therefore, the …
and affected patients frequently report impairments in quality of life (QoL). Therefore, the …
Trajectories and determinants of functional limitations in late-life depression: a 2-year prospective cohort study
S Wassink-Vossen, RM Collard, KJ Wardenaar… - European …, 2019 - cambridge.org
Background: In mental health research, functional recovery is increasingly valued as an
important outcome in addition to symptomatic remission. Methods: Course types of …
important outcome in addition to symptomatic remission. Methods: Course types of …
In pursuit of full recovery in major depressive disorder
Many individuals with major depression disorder (MDD) who achieve remission of
depressive symptoms, do not perceive themselves as fully recovered. This study explores …
depressive symptoms, do not perceive themselves as fully recovered. This study explores …
The relative importance of diagnostic specific and transdiagnostic factors in evaluating treatment outcome of depressed patients
Determinations of the efficacy of treatments for depression most commonly are based on
changes in scores on symptom severity scales. This narrow symptom-focused approach …
changes in scores on symptom severity scales. This narrow symptom-focused approach …
[HTML][HTML] Deep immunophenoty** of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment …
F Stolfi, C Brasso, D Raineri, V Landra… - Brain, Behavior, & …, 2025 - Elsevier
Abstract Major Depressive Disorder (MDD) is a widespread psychiatric condition impacting
social and occupational functioning, making it a leading cause of disability. The diagnosis of …
social and occupational functioning, making it a leading cause of disability. The diagnosis of …