Phosgene (carbonyl dichloride) gas is an indispensable high-production-volume chemical
intermediate used worldwide in numerous industrial processes. Published evidence of …

Unrestrained plethysmography (UP) has been widely used to measure airway reactivity in
conscious mice. It is non-invasive, easy to use, suitable for longitudinal studies, and allows a …

Pulmonary function analysis is an important tool in the evaluation of mouse respiratory
disease models, but much controversy still exists on the validity of some tests. Most …

Many papers in the AJRCMB make efforts to translate basic cell and molecular insights to
the effects on airways in the whole animal. However, these efforts are often ffawed by an …

There has been significant utilization of the technique described by Hamelmann et al.(Am J
Respir Crit Care Med 156: 766–775, 1997) in which a parameter, enhanced pause (Penh) …

Experimental mouse models of allergic asthma established almost 10 years ago offered new
opportunities to study disease pathogenesis and to develop new therapeutics. These …

Interleukin (IL)-17F is a recently described human cytokine belonging to the IL-17 gene
family, but its in vivo function remains to be determined. To this end, a full-length mouse IL …

The widespread use of genetically altered mouse models of experimental asthma has
stimulated the development of lung function techniques in vivo to characterize the functional …

Research using animal models of asthma is currently dominated by mouse models. This has
been driven by the comprehensive knowledge on inflammatory and immune reactions in …

Objective: Epidemiological studies have shown that elevated concentrations of ambient
particulate matter (aerodynamic diameter≤ 2.5 μm; PM2. 5) correlates with increased …