Cell cycle control in cancer
Cancer is a group of diseases in which cells divide continuously and excessively. Cell
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
division is tightly regulated by multiple evolutionarily conserved cell cycle control …
Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution
Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
Cell cycle dysregulation in cancer
A Glaviano, SK Singh, EHC Lee, E Okina… - Pharmacological …, 2024 - Elsevier
Cancer is a systemic manifestation of aberrant cell cycle activity and dysregulated cell
growth. Genetic mutations can determine tumor onset by either augmenting cell division …
growth. Genetic mutations can determine tumor onset by either augmenting cell division …
Targeting mitosis exit: a brake for cancer cell proliferation
The transition from mitosis to interphase, referred to as mitotic exit, is a critical mitotic
process which involves activation and inactivation of multiple mitotic kinases and …
process which involves activation and inactivation of multiple mitotic kinases and …
Generation of two paclitaxel-resistant high-grade serous carcinoma cell lines with increased expression of p-glycoprotein
Debulking surgery followed by chemotherapy are the standard of care for high-grade serous
carcinoma. After an initial good response to treatment, the majority of patients relapse with a …
carcinoma. After an initial good response to treatment, the majority of patients relapse with a …
BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
J Mann, N Yang, R Montpetit, R Kirschenman… - Scientific reports, 2020 - nature.com
Breast cancer patients are commonly treated with taxane (eg docetaxel) chemotherapy,
despite poor outcomes and eventual disease relapse. We previously identified the Bcl-2 …
despite poor outcomes and eventual disease relapse. We previously identified the Bcl-2 …
Regulatory miRNAs, circRNAs and lncRNAs in cell cycle progression of breast cancer
H Chen, G **e, Q Luo, Y Yang, S Hu - Functional & Integrative Genomics, 2023 - Springer
Breast cancer is a complex and heterogeneous disease that poses a significant public
health concern worldwide, and it remains a major challenge despite advances in treatment …
health concern worldwide, and it remains a major challenge despite advances in treatment …
Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic
Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly
checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape …
checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape …
Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction
Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (eg,
MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule …
MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule …
Spindly and Bub3 expression in oral cancer: Prognostic and therapeutic implications
Abstract Objectives Bub3 and Spindly are essential proteins required for the activation and
inactivation of the spindle assembly checkpoint, respectively. Here, we explored the …
inactivation of the spindle assembly checkpoint, respectively. Here, we explored the …