Same substrate, many reactions: oxygen activation in flavoenzymes
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Flavin dependent monooxygenases
MME Huijbers, S Montersino, AH Westphal… - Archives of biochemistry …, 2014 - Elsevier
Flavin-dependent monooxygenases catalyze a wide variety of chemo-, regio-and
enantioselective oxygenation reactions. As such, they are involved in key biological …
enantioselective oxygenation reactions. As such, they are involved in key biological …
Unifying and versatile features of flavin-dependent monooxygenases: Diverse catalysis by a common C4a-(hydro) peroxyflavin
Flavin-dependent monooxygenases (FDMOs) are known for their remarkable versatility and
for their crucial roles in various biological processes and applications. Extensive research …
for their crucial roles in various biological processes and applications. Extensive research …
Monooxygenation of aromatic compounds by flavin‐dependent monooxygenases
P Chenprakhon, T Wongnate, P Chaiyen - Protein Science, 2019 - Wiley Online Library
Many flavoenzymes catalyze hydroxylation of aromatic compounds especially phenolic
compounds have been isolated and characterized. These enzymes can be classified as …
compounds have been isolated and characterized. These enzymes can be classified as …
Multiple pathways guide oxygen diffusion into flavoenzyme active sites
R Baron, C Riley, P Chenprakhon… - Proceedings of the …, 2009 - National Acad Sciences
Dioxygen (O2) and other gas molecules have a fundamental role in a variety of enzymatic
reactions. However, it is only poorly understood which O2 uptake mechanism enzymes …
reactions. However, it is only poorly understood which O2 uptake mechanism enzymes …
The FMN-dependent two-component monooxygenase systems
HR Ellis - Archives of biochemistry and biophysics, 2010 - Elsevier
The FMN-dependent two-component monooxygenase systems catalyze a diverse range of
reactions. These two-component systems are composed of an FMN reductase enzyme and …
reactions. These two-component systems are composed of an FMN reductase enzyme and …
Mechanism of oxygen activation in a flavin-dependent monooxygenase: a nearly barrierless formation of C4a-hydroperoxyflavin via proton-coupled electron transfer
S Visitsatthawong, P Chenprakhon… - Journal of the …, 2015 - ACS Publications
Understanding how flavin-dependent enzymes activate oxygen for their oxidation and
oxygenation reactions is one of the most challenging issues in flavoenzymology. Density …
oxygenation reactions is one of the most challenging issues in flavoenzymology. Density …
Properties and mechanisms of flavin-dependent monooxygenases and their applications in natural product synthesis
Natural products are usually highly complicated organic molecules with special scaffolds,
and they are an important resource in medicine. Natural products with complicated …
and they are an important resource in medicine. Natural products with complicated …
Mechanisms of reduced flavin transfer in the two-component flavin-dependent monooxygenases
J Sucharitakul, R Tinikul, P Chaiyen - Archives of biochemistry and …, 2014 - Elsevier
Two-component flavin-dependent enzymes are abundant in nature and are involved in a
wide variety of biological reactions. These enzymes consist of a reductase which generates …
wide variety of biological reactions. These enzymes consist of a reductase which generates …
A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism
C Dresen, LYC Lin, I D'Angelo, EI Tocheva… - Journal of Biological …, 2010 - ASBMB
Mycobacterium tuberculosis (Mtb) and Rhodococcus jostii RHA1 have similar cholesterol
catabolic pathways. This pathway contributes to the pathogenicity of Mtb. The hsaAB …
catabolic pathways. This pathway contributes to the pathogenicity of Mtb. The hsaAB …