Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
[HTML][HTML] The ErbB signaling network: receptor heterodimerization in development and cancer
MA Olayioye, RM Neve, HA Lane, NE Hynes - The EMBO journal, 2000 - embopress.org
Cells are continuously exposed to diverse stimuli ranging from soluble endocrine and
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …
paracrine factors, to signaling molecules on neighboring cells. It is of great importance that …
Estrogen receptors: how do they signal and what are their targets
During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …
Epidermal growth factor receptor: mechanisms of activation and signalling
Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer
CM Nelson, MJ Bissell - Annu. Rev. Cell Dev. Biol., 2006 - annualreviews.org
The microenvironment influences gene expression so that the behavior of a cell is largely
determined by its interactions with the extracellular matrix, neighboring cells, and soluble …
determined by its interactions with the extracellular matrix, neighboring cells, and soluble …
Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype
Gene targeting was used to create a null allele at the epidermal growth factor receptor locus
(Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 …
(Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 …
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
PJ Miettinen, JE Berger, J Meneses, Y Phung… - Nature, 1995 - nature.com
SINCE the discovery that epidermal growth factor (EGF) can accelerate opening of the
eyelids1, the EGF receptor (EGF-R) has been extensively studied and is now considered to …
eyelids1, the EGF receptor (EGF-R) has been extensively studied and is now considered to …
Strain-dependent epithelial defects in mice lacking the EGF receptor
Mice and cells lacking the epidermal growth factor receptor (EGFR) were generated to
examine its physiological role in vivo. Mutant fetuses are retarded in growth and die at mid …
examine its physiological role in vivo. Mutant fetuses are retarded in growth and die at mid …
Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
D Harari, Y Yarden - Oncogene, 2000 - nature.com
Overexpression of ErbB2, a receptor-like tyrosine kinase, is shared by several types of
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …
human carcinomas. In breast tumors the extent of overexpression has a prognostic value …
Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in …
F Wang, VM Weaver, OW Petersen… - Proceedings of the …, 1998 - National Acad Sciences
Anchorage and growth factor independence are cardinal features of the transformed
phenotype. Although it is logical that the two pathways must be coregulated in normal …
phenotype. Although it is logical that the two pathways must be coregulated in normal …