Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Many lines of evidence suggest that mitochondria have a central role in ageing-related
neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature …

That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Parkinson's disease is the second most common neurodegenerative disorder and is
characterized by the degeneration of dopaminergic neurons in the substantia nigra …

Autosomal recessive juvenile parkinsonism (AR-JP) is an early-onset form of Parkinson's
disease characterized by motor disturbances and dopaminergic neurodegeneration,. To …

The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria,
indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ …

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …