Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Curcumin is a polyphenol natural product isolated from turmeric, interacting with different
cellular and molecular targets and, consequently, showing a wide range of pharmacological …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Tumor cells undergoing immunogenic cell death (ICD) release immunogenic damage-
associated molecular patterns (DAMPs) to trigger a long-term protective antitumor response …

Naive lymphocytes continually enter and exit lymphoid organs in a recirculation process that
is essential for immune surveillance. During immune responses, the egress process can be …

Inflammation has been involved in the pathophysiology and treatment response of major
depressive disorder (MDD). Plasma cytokine profiles of 171 treatment-naive MDD patients …

Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …

Although the classification of cell types often relies on the identification of cell surface
proteins as differentiation markers, flow cytometry requires suitable antibodies and currently …

Chronic inflammation is accompanied by impaired T-cell immunity. In the mouse, myeloid
cell-associated arginase accounts for the suppression of immune reactivity in various …

Background Age-related macular degeneration (AMD) is a leading cause of blindness that
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …