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Transcriptional control of energy metabolism by nuclear receptors
Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …
respond to physiological cues to generate the energy required for anabolic pathways …
Nuclear receptor crosstalk—defining the mechanisms for therapeutic innovation
Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlap** signalling pathways. A subset of nuclear receptors …
receptors or between their overlap** signalling pathways. A subset of nuclear receptors …
Mechanisms of estrogen action
S Nilsson, S Makela, E Treuter… - Physiological …, 2001 - journals.physiology.org
Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …
which estrogens bring about these functions has changed during the past decade. Just as …
Transcriptional regulation of adipogenesis
The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …
regulation of differentiation for a whole host of specific cell types. The development of …
Transcriptional integration of mitochondrial biogenesis
Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial
biogenesis and function. Some of these factors act exclusively within the mitochondria to …
biogenesis and function. Some of these factors act exclusively within the mitochondria to …
Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
We are witnessing a period of renewed interest in the biology of the mitochondrion. The
mitochondrion serves a critical function in the maintenance of cellular energy stores …
mitochondrion serves a critical function in the maintenance of cellular energy stores …
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Ischaemia of the heart, brain and limbs is a leading cause of morbidity and mortality
worldwide. Hypoxia stimulates the secretion of vascular endothelial growth factor (VEGF) …
worldwide. Hypoxia stimulates the secretion of vascular endothelial growth factor (VEGF) …
Molecular regulation of adipogenesis
▪ Abstract Adipogenesis, or the development of fat cells from preadipocytes, has been one of
the most intensely studied models of cellular differentiation. In part this has been because of …
the most intensely studied models of cellular differentiation. In part this has been because of …
Mitochondrial biogenesis and dynamics in the develo** and diseased heart
The mitochondrion is a complex organelle that serves essential roles in energy transduction,
ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network …
ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network …
Thiadiazole—A promising structure in medicinal chemistry
Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …