Development and application of bond cleavage reactions in bioorthogonal chemistry
J Li, PR Chen - Nature Chemical Biology, 2016 - nature.com
Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as
an unprecedented technique to dissect native biological processes through chemistry …
an unprecedented technique to dissect native biological processes through chemistry …
Small GTP-binding proteins
Y Takai, T Sasaki, T Matozaki - Physiological reviews, 2001 - journals.physiology.org
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …
constitute a superfamily consisting of more than 100 members. This superfamily is …
[HTML][HTML] The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies
M De Robertis, E Massi, ML Poeta, S Carotti… - Journal of …, 2011 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is a major health problem in industrialized countries. Although
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …
inflammation-linked carcinogenesis is a well accepted concept and is often observed within …
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
We have investigated the in vivo functional role of rab5, a small GTPase associated with the
plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein …
plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein …
The Ras protein superfamily: evolutionary tree and role of conserved amino acids
The Ras superfamily is a fascinating example of functional diversification in the context of a
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …
preserved structural framework and a prototypic GTP binding site. Thanks to the availability …
Mutations Affecting G-Protein Subunit α11 in Hypercalcemia and Hypocalcemia
Background Familial hypocalciuric hypercalcemia is a genetically heterogeneous disorder
with three variants: types 1, 2, and 3. Type 1 is due to loss-of-function mutations of the …
with three variants: types 1, 2, and 3. Type 1 is due to loss-of-function mutations of the …
Structure-function relationships of the G domain, a canonical switch motif
A Wittinghofer, IR Vetter - Annual review of biochemistry, 2011 - annualreviews.org
GTP-binding (G) proteins constitute a class of P-loop (phosphate-binding loop) proteins that
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …
work as molecular switches between the GDP-bound OFF and the GTP-bound ON state. The …
Rac and Rho GTPases in cancer cell motility control
M Parri, P Chiarugi - Cell communication and signaling, 2010 - Springer
Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton
organization, migration, transcription, and proliferation. A common theme of these processes …
organization, migration, transcription, and proliferation. A common theme of these processes …
Evolution of the Rab family of small GTP-binding proteins
Rab proteins are small GTP-binding proteins that form the largest family within the Ras
superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane …
superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane …
Blocking oncogenic Ras signaling for cancer therapy
AA Adjei - Journal of the National Cancer Institute, 2001 - academic.oup.com
The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …