The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Gonadal hormones play a key role in the establishment, activation, and regulation of the
hypothalamic–pituitary–adrenal (HPA) axis. By influencing the response and sensitivity to …

The gonadotropin-releasing hormone (GnRH) neuronal network generates pulse and surge
modes of gonadotropin secretion critical for puberty and fertility. The arcuate nucleus …

BACKGROUND The discovery of kisspeptin as key central regulator of GnRH secretion has
led to a new level of understanding of the neuroendocrine regulation of human reproduction …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably
soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast …

Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex.
These cell-based clocks have been conceptualized as oscillators whose phase can be reset …

BACKGROUND Kisspeptin is a key regulator of hypothalamic gonadotropin-releasing
hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin …