Lipid-based nanoparticles for drug/gene delivery: an overview of the production techniques and difficulties encountered in their industrial development

M Mehta, TA Bui, X Yang, Y Aksoy, EM Goldys… - ACS Materials …, 2023 - ACS Publications
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …

Cell membrane-coated nanoparticles: a novel multifunctional biomimetic drug delivery system

H Liu, YY Su, XC Jiang, JQ Gao - Drug Delivery and Translational …, 2023 - Springer
Recently, nanoparticle-based drug delivery systems have been widely used for the
treatment, prevention, and detection of diseases. Improving the targeted delivery ability of …

Advances and limitations of drug delivery systems formulated as eye drops

C Jumelle, S Gholizadeh, N Annabi, R Dana - Journal of Controlled …, 2020 - Elsevier
Topical instillation of eye drops remains the most common and easiest route of ocular drug
administration, representing the treatment of choice for many ocular diseases. Nevertheless …

Stability characterization for pharmaceutical liposome product development with focus on regulatory considerations: An update

VGSS Jyothi, R Bulusu, BVK Rao, M Pranothi… - International Journal of …, 2022 - Elsevier
Liposomes have several advantages, such as the ability to be employed as a carrier/vehicle
for a variety of drug molecules and at the same time they are safe and biodegradable. In the …

Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures

H Ragelle, F Danhier, V Préat, R Langer… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Nanomedicine has emerged as a major field of academic research with direct
impact on human health. While a first generation of products has been successfully …

BCS class IV drugs: Highly notorious candidates for formulation development

R Ghadi, N Dand - Journal of Controlled Release, 2017 - Elsevier
BCS class IV drugs (eg, amphotericin B, furosemide, acetazolamide, ritonavir, paclitaxel)
exhibit many characteristics that are problematic for effective oral and per oral delivery …

In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles

US Patil, S Adireddy, A Jaiswal, S Mandava… - International journal of …, 2015 - mdpi.com
Increasing biomedical applications of iron oxide nanoparticles (IONPs) in academic and
commercial settings have alarmed the scientific community about the safety and assessment …

Sterilization of hydrogels for biomedical applications: A review

R Galante, TJA Pinto, R Colaco… - Journal of Biomedical …, 2018 - Wiley Online Library
Despite the beneficial properties and outstanding potential of hydrogels for biomedical
applications, several unmet challenges must be overcome, especially regarding to their …

Polymer-based carriers for ophthalmic drug delivery

JC Imperiale, GB Acosta, A Sosnik - Journal of controlled release, 2018 - Elsevier
Despite the wide range of diseases affecting the eye, ocular bioavailability remains a
challenge in ophthalmic drug delivery. Nowadays an extensive variety of polymers are being …

Endotoxin contamination: a key element in the interpretation of nanosafety studies

Y Li, D Boraschi - Nanomedicine, 2016 - Taylor & Francis
The study of toxicity and potential risks of engineered nanoparticles is of particular
importance in nanomedicine. Endotoxin, a common contaminant of bacterial origin, has …