The diversification of methods for studying cell–cell interactions and communication
No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …
Single-cell omics: experimental workflow, data analyses and applications
Cells are the fundamental units of biological systems and exhibit unique development
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
trajectories and molecular features. Our exploration of how the genomes orchestrate the …
LIANA+ provides an all-in-one framework for cell–cell communication inference
The growing availability of single-cell and spatially resolved transcriptomics has led to the
development of many approaches to infer cell–cell communication, each capturing only a …
development of many approaches to infer cell–cell communication, each capturing only a …
Epsin nanotherapy regulates cholesterol transport to fortify atheroma regression
Background: Excess cholesterol accumulation in lesional macrophages elicits complex
responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of …
responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of …
Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system
The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …
host against a wide range of pathogenic threats. Recent advancements in single-cell and …
Metabolic reprogramming and heterogeneity during the decidualization process of endometrial stromal cells
Z Jia, Y Wei, Y Zhang, K Song, J Yuan - Cell Communication and Signaling, 2024 - Springer
The human endometrial decidualization is a transformative event in the pregnant uterus that
involves the differentiation of stromal cells into decidual cells. While crucial to the …
involves the differentiation of stromal cells into decidual cells. While crucial to the …
LIANA+: an all-in-one cell-cell communication framework
The growing availability of single-cell and spatially-resolved transcriptomics has led to the
rapidly growing popularity of methods to infer cell-cell communication. Many approaches …
rapidly growing popularity of methods to infer cell-cell communication. Many approaches …
A comparison of cell-cell interaction prediction tools based on scrna-seq data
Z **e, X Li, A Mora - Biomolecules, 2023 - mdpi.com
Computational prediction of cell-cell interactions (CCIs) is becoming increasingly important
for understanding disease development and progression. We present a benchmark study of …
for understanding disease development and progression. We present a benchmark study of …
Integrated single-cell analysis reveals distinct epigenetic-regulated cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer
Background Inter-and intra-tumor heterogeneity is considered a significant factor
contributing to the development of endocrine resistance in breast cancer. Recent advances …
contributing to the development of endocrine resistance in breast cancer. Recent advances …
[HTML][HTML] Metabolic crosstalk between stromal and malignant cells in the bone marrow niche
Bone marrow is the primary site of blood cell production in adults and serves as the source
of osteoblasts and osteoclasts that maintain bone homeostasis. The medullary …
of osteoblasts and osteoclasts that maintain bone homeostasis. The medullary …