Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Over the past 10 years, mitochondrial defects have been implicated in a wide variety of
degenerative diseases, aging, and cancer. Studies on patients with these diseases have …

Mitochondria play a central role in cellular energy provision. The organelles contain their
own genome with a modified genetic code. The mammalian mitochondrial genome is …

Mutations in the human mitochondrial genome are known to cause an array of diverse
disorders, most of which are maternally inherited, and all of which are associated with …

Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of
degenerative processes may be associated with defects in oxidative phosphorylation …

Recent studies using magnetic resonance spectroscopy have shown that decreased insulin-
stimulated muscle glycogen synthesis due to a defect in insulin-stimulated glucose transport …

A major theory of aging is that oxidative damage may accumulate in DNA and contribute to
physiological changes associated with aging. We examined age‐related accumulation of …

Mitochondria are one of the enzymatic sources of reactive oxygen species (ROS) and could
also be a major target for ROS-mediated damage. We hypothesized that ROS may induce …

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive
human disease associated with multiple deletions of skeletal muscle mitochondrial DNA …