Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

Analgesic therapies are still limited and sometimes poorly effective, therefore finding new
targets for the development of innovative drugs is urgently needed. In order to validate the …

Antiepileptic drugs (AEDs) are commonly prescribed for nonepileptic conditions, including
migraine headache, chronic neuropathic pain, mood disorders, schizophrenia and various …

The last few years have brought about many changes in the field of marine and freshwater
toxins, with advances in analytical technology and the realization that these toxins are a …

Pfaff presents a daring perspective on the long-standing puzzle of what arousal is. He
argues that, beneath our mental functions and emotional dispositions, a primitive neuronal …

The thalamus is a key relay station for the transmission of nociceptive information to the
cerebral cortex. We review the input–output connection, functional imaging, direct neuronal …

Hydrogen sulfide is an endogenously produced gas in the central nervous system and has
been touted as the body's third gaseous signaling molecule after nitric oxide and carbon …

Although T‐type Ca2+ channels are implicated in nociception, the function of specific
subtypes has not been well defined. Here, we compared pain susceptibility in mice lacking …