Microneedle biomedical devices

M Zheng, T Sheng, J Yu, Z Gu, C Xu - Nature Reviews Bioengineering, 2024‏ - nature.com
Microneedle (MN) technologies have gained interest for biomedical applications, ranging
from drug delivery to sensing and tissue sampling in skin and internal organs. The …

Engineering microneedle patches for improved penetration: analysis, skin models and factors affecting needle insertion

P Makvandi, M Kirkby, ARJ Hutton, M Shabani… - Nano-Micro Letters, 2021‏ - Springer
Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety
of active compounds into the skin. To serve as a substitute for common hypodermic needles …

Scarless wound healing programmed by core-shell microneedles

Y Zhang, S Wang, Y Yang, S Zhao, J You… - Nature …, 2023‏ - nature.com
Effective reprogramming of chronic wound healing remains challenging due to the limited
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023‏ - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

A wearable touch‐activated device integrated with hollow microneedles for continuous sampling and sensing of dermal interstitial fluid

T Abbasiasl, F Mirlou, H Mirzajani… - Advanced …, 2024‏ - Wiley Online Library
Dermal interstitial fluid (ISF) is emerging as a rich source of biomarkers that complements
conventional biofluids such as blood and urine. However, the impact of ISF sampling in …

Microneedle-mediated transdermal drug delivery for treating diverse skin diseases

D Yang, M Chen, Y Sun, Y **, C Lu, X Pan, G Quan… - Acta Biomaterialia, 2021‏ - Elsevier
Transdermal drug delivery is an attractive route for dermatological disease therapy because
it can directly target the lesion site on the skin, reduce adverse reactions associated with …

Nanomaterials for biomedical applications: production, characterisations, recent trends and difficulties

M Mabrouk, DB Das, ZA Salem, HH Beherei - Molecules, 2021‏ - mdpi.com
Designing of nanomaterials has now become a top-priority research goal with a view to
develo** specific applications in the biomedical fields. In fact, the recent trends in the …

3D printed microneedles for anticancer therapy of skin tumours

MJ Uddin, N Scoutaris, SN Economidou… - Materials Science and …, 2020‏ - Elsevier
In this study, novel 3D printed polymeric microneedle arrays were fabricated for enhanced
cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment. The microneedles …

3D-printed microneedles in biomedical applications

SR Dabbagh, MR Sarabi, R Rahbarghazi, E Sokullu… - Iscience, 2021‏ - cell.com
Conventional needle technologies can be advanced with emerging nano-and micro-
fabrication methods to fabricate microneedles. Nano-/micro-fabricated microneedles seek to …

A hydrogel microneedle patch for point‐of‐care testing based on skin interstitial fluid

R He, Y Niu, Z Li, A Li, H Yang, F Xu… - Advanced Healthcare …, 2020‏ - Wiley Online Library
Skin interstitial fluid (ISF) holds great potential as a highly desirable sample resource for
point‐of‐care testing (POCT), where the key is to effectively collect target biomarkers from …