Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …

Objectives The aim of our study was to determine whether there is a correlation between
transcription factors expression and Th17/Treg ratio, cytokine profile in the RA phenotype as …

Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative
colitis (UC), represents a group of chronic disorders characterized by inflammation of the …

Proinflammatory Th17 cells and CD4+ CD25+ regulatory T (Treg) cells are two newly
identified T lymphocyte subsets, which have opposite effects on autoimmunity and …

Context: Th17 lymphocytes play an important role in different chronic inflammatory and
autoimmune conditions. Aim: The aim of the study was to explore the status of Th17 cells in …

The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic
CD4+ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase …

Benign prostatic hyperplasia (BPH) is a common disorder affecting 50–80% of the aged
male population. Androgens and age have been traditionally considered the main …

Nuclear factor-κB (NF-κB) is an inducible transcription factor controlled by two principal
signaling cascades, each activated by a set of signal ligands: the classical/canonical NF-κB …

Objective To explore the mechanism of Etanercept in the treatment of rheumatoid arthritis
(RA), we investigated whether the Th1/Th2 and Th17/regulatory T cells (Treg) imbalance …