To perform computations with the efficiency necessary for animal survival, neocortical
microcircuits must be capable of reconfiguring in response to experience, while carefully …

Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

Complex neuronal circuitries such as those found in the mammalian cerebral cortex have
evolved as balanced networks of excitatory and inhibitory neurons. Although the …

Since the discovery of ocular dominance plasticity, neuroscientists have understood that
changes in visual experience during a discrete developmental time, the critical period …

Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …

Neural circuits must maintain stable function in the face of many plastic challenges,
including changes in synapse number and strength, during learning and development …

Microglia were recently shown to play unexpected roles in normal brain development and
adult physiology. This has begun to dramatically change our view of these resident …

The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …

Microglia are the immune cells of the brain. In the absence of pathological insult, their highly
motile processes continually survey the brain parenchyma and transiently contact synaptic …

How learning enhances neural representations for behaviorally relevant stimuli via activity
changes of cortical cell types remains unclear. We simultaneously imaged responses of …