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Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials
H Zhang, X Yue, Z Chen, C Liu, W Wu, N Zhang, Z Liu… - Molecular Cancer, 2023 - Springer
Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …
Glioblastoma heterogeneity at single cell resolution
D Eisenbarth, YA Wang - Oncogene, 2023 - nature.com
Glioblastoma (GBM) is one of the deadliest types of cancer and highly refractory to
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …
chemoradiation and immunotherapy. One of the main reasons for this resistance to therapy …
State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis
Introduction Fibroblast activation protein-α (FAPα) is overexpressed on cancer-associated
fibroblasts in approximately 90% of epithelial neoplasms, representing an appealing target …
fibroblasts in approximately 90% of epithelial neoplasms, representing an appealing target …
Tumor buster-where will the CAR-T cell therapy 'missile'go?
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …
technology represents a significant breakthrough in personalized immunotherapy for human …
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
Background Aggressive primary brain tumors such as glioblastoma are uniquely
challenging to treat. The intracranial location poses barriers to therapy, and the potential for …
challenging to treat. The intracranial location poses barriers to therapy, and the potential for …
Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution
F Zhang, Y Ma, D Li, J Wei, K Chen, E Zhang… - Journal of Hematology & …, 2024 - Springer
Metabolic reprogramming provides tumors with an energy source and biofuel to support
their survival in the malignant microenvironment. Extensive research into the intrinsic …
their survival in the malignant microenvironment. Extensive research into the intrinsic …
[HTML][HTML] Unravelling glioblastoma heterogeneity by means of single-cell RNA sequencing
AH Martínez, R Madurga, N García-Romero… - Cancer letters, 2022 - Elsevier
Glioblastoma (GBM) is the most invasive and deadliest brain cancer in adults. Its inherent
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …
Tumor immune microenvironment and its related miRNAs in tumor progression
Y ** the immune microenvironment of glioblastoma: implications for immunotherapy
Glioblastoma is the most common form of primary brain tumour in adults. For more than a
decade, conventional treatment has produced a relatively modest improvement in the …
decade, conventional treatment has produced a relatively modest improvement in the …