Background Peroxisomes are single membrane-bound organelles named for their role in
hydrogen peroxide production and catabolism. However, their cellular functions extend well …

With the increase in life expectancy, aging has emerged as a significant health concern. Due
to its various mechanisms of action, cardiometabolic drugs are often repurposed for other …

Coordination of cellular responses to stress is essential for health across the lifespan. The
transcription factor SKN-1 is an essential homeostat that mediates survival in stress-inducing …

Aging is generally regarded as an irreversible process, and its intricate relationship with the
immune system has garnered significant attention due to its profound implications for the …

The presence of membrane-bound organelles with specific functions is one of the main
hallmarks of eukaryotic cells. Organelle membranes are composed of specific lipids that …

Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role
in the regulation of longevity. However, identification of universally conserved complex lipid …

Calorie restriction (CR) and physical exercise (EX) are well‐established interventions known
to extend health span and lifespan in animal models. However, their impact on human …

When an organism encounters a pathogen, the host innate immune system activates to
defend against pathogen colonization and toxic xenobiotics produced. C. elegans employ …

Yeast is an excellent model organism for research for regulating aging and lifespan, and the
studies have made many contributions to date, including identifying various factors and …

Centenarians and their relatives possess a notable survival advantage, with higher longevity
and reduced susceptibility to major age‐related diseases. To date, characteristic omics …