VHH, ie, VH domains of camelid single-chain antibodies, are very promising therapeutic
agents due to their significant physicochemical advantages compared to classical …

Dynamical behaviour is one of the most crucial protein characteristics. Despite the advances
in the field of protein structure resolution and prediction, analysis and prediction of protein …

Antigen binding by antibodies requires precise orientation of the complementarity-
determining region (CDR) loops in the variable domain to establish the correct contact …

N-methyl-D-aspartate receptors (NMDARs) mediate excitatory synaptic transmission in the
central nervous system, underlie the induction of synaptic plasticity, and their malfunction is …

Abstract Heavy Chain Only Antibodies are specific to Camelid species. Despite the lack of
the light chain variable domain, their heavy chain variable domain (VH) domain, named …

Protein structures are highly dynamic macromolecules. This dynamics is often analysed
through experimental and/or computational methods only for an isolated or a limited number …

Post-translational modifications (PTMs) are known to play a critical role in the regulation of
protein functions. Their impact on protein structures and their link to disorder regions have …

Background Protein 3D structure is the support of its function. Comparison of 3D protein
structures provides insight on their evolution and their functional specificities and can be …

Essential thrombocythemia (ET) is a blood cancer. ET is characterized by an overproduction
of platelets that can lead to thrombosis formation. Platelet overproduction occurs in …

Sequence–structure–function paradigm has been revolutionized by the discovery of
disordered regions and disordered proteins more than two decades ago. While the definition …