Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Although over 90 independent risk variants have been identified for Parkinson's disease
using genome-wide association studies, most studies have been performed in just one …

The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …

ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …

The etiology of idiopathic Parkinson's disease (iPD) is multifactorial, and both genetics and
environmental exposures are risk factors. While mutations in leucine-rich repeat kinase-2 …

We previously reported that Parkinson's disease (PD) kinase LRRK2 phosphorylates a
subset of Rab GTPases on a conserved residue in their switch-II domains (Steger et al …

Parkinson's disease is a debilitating, age-associated movement disorder. A central aspect of
the pathophysiology of Parkinson's disease is the progressive demise of midbrain dopamine …

Parkinson's disease-causing mutations in the leucine-rich repeat kinase 2 (LRRK2) gene
hyperactivate LRRK2 kinase activity and cause increased phosphorylation of Rab GTPases …