[HTML][HTML] Biomechanical modeling of progressive wound healing: a computational study

G Singh, A Chanda - Biomedical Engineering Advances, 2022 - Elsevier
Skin injury is the most common type of injury, which manifests itself in the form of wounds
and cuts. Wound healing, which typically involves the formation of a clot, is a complex …

Langerhans cells and SFRP2/Wnt/beta‐catenin signalling control adaptation of skin epidermis to mechanical stretching

JK Ledwon, EE Vaca, CC Huang… - Journal of cellular …, 2022 - Wiley Online Library
Skin can be mechanically stimulated to grow through a clinical procedure called tissue
expansion (TE). Using a porcine TE model, we determined that expansion promptly …

Bayesian calibration of a computational model of tissue expansion based on a porcine animal model

T Han, T Lee, J Ledwon, E Vaca, S Turin, A Kearney… - Acta biomaterialia, 2022 - Elsevier
Tissue expansion is a technique used clinically to grow skin in situ to correct large defects.
Despite its enormous potential, lack of fundamental knowledge of skin adaptation to …

Multi-fidelity gaussian process surrogate modeling of pediatric tissue expansion

T Han, KS Ahmed, AK Gosain… - Journal of …, 2022 - asmedigitalcollection.asme.org
Growth of skin in response to stretch is the basis for tissue expansion (TE), a procedure to
gain new skin area for reconstruction of large defects. Unfortunately, complications and …

The role of interface geometry and appendages on the mesoscale mechanics of the skin

O Moreno-Flores, MK Rausch, AB Tepole - Biomechanics and Modeling in …, 2024 - Springer
The skin is the largest organ in the human body and serves various functions, including
mechanical protection and mechanosensation. Yet, even though skin's biomechanics are …

Tissue expansion mitigates radiation-induced skin fibrosis in a porcine model

L Nunez-Alvarez, JK Ledwon, S Applebaum, B Progri… - Acta Biomaterialia, 2024 - Elsevier
Tissue expansion (TE) is the primary method for breast reconstruction after mastectomy. In
many cases, mastectomy patients undergo radiation treatment (XR). Radiation is known to …

Numerical investigation of new rete ridge formation in a multi-layer model of skin subjected to tissue expansion

O Moreno-Flores, M Holland, J Ledwon… - Journal of …, 2024 - Elsevier
The skin is a multilayered organ with microstructural and antomical heterogeneities that
contribute to its unique mechanophysiology. Between the epidermis layer at the top and the …

Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor

S Shan, J He, Q Sun, K Zhu, Y Li, B Reid… - Experimental …, 2023 - Wiley Online Library
Skin expands and regenerates in response to mechanical stretch. This important
homeostasis process is critical for skin biology and can be exploited to generate extra skin …

Acellular dermal matrix cover improves skin growth during tissue expansion by affecting distribution of mechanical forces

JK Ledwon, SA Applebaum, B Progri… - Plastic and …, 2024 - journals.lww.com
Background: Biological cover over tissue expander prostheses has been introduced to
provide soft-tissue support for tissue expanders during breast reconstruction. However, its …

The Dynamic Changes in Skin Thickness of Forehead during Tissue Expansion

Z Song, X Zhang, Y Xu, J You, H Wang… - Facial Plastic …, 2024 - thieme-connect.com
In addition to providing extra flap size, the tissue expansion process also brings changes in
flap thickness. This study aims to identify the changes in the forehead flap thickness during …