Highlights•Microbial production of biofuels and commodity chemicals from natural gas and
methanol.•Engineering platform organisms to utilize methanol for producing small …

Methanol is one of the building blocks in the chemical industry and can be synthesized
either from petrochemical or renewable resources, such as biogas. Bioprocess technology …

The current climatic change is predominantly driven by excessive anthropogenic CO2
emissions. As industrial bioprocesses primarily depend on food-competing organic …

Synthetic methylotrophy has recently been intensively studied to achieve methanol-based
biomanufacturing of fuels and chemicals. However, attempts to engineer platform …

Methanol has recently gained significant attention as a potential carbon substrate for the
production of fuels and chemicals, owing to its high degree of reduction, abundance, and …

The increasing availability and affordability of natural gas has renewed interest in using
methanol for bioproduction of useful chemicals. Engineering synthetic methylotrophy based …

Methanol is an important feedstock derived from natural gas and can be chemically
converted into commodity and specialty chemicals at high pressure and temperature …

Formaldehyde metabolism is prevalent in all organisms, where the accumulation of
formaldehyde can be prevented through the activity of dissimilation pathways. Furthermore …

Highlights•Engineering aerobic and anaerobic methane activation for fuel and chemical
production.•Develo** synthetic methylotrophs for conversion of methanol to fuels and …

Synthetic methylotrophy aims to develop non-native methylotrophic microorganisms to
utilize methane or methanol to produce chemicals and biofuels. We report two …