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Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions
M Dierssen, M Fructuoso… - Frontiers in …, 2020 - frontiersin.org
Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual
disability, resulting from the presence of an extra complete or segment of chromosome 21 …
disability, resulting from the presence of an extra complete or segment of chromosome 21 …
The role of taurine through endoplasmic reticulum in physiology and pathology
L Wang, Z ** down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model
C Lanzillotta, MR Baniowska, F Prestia, C Sette… - Neurobiology of …, 2024 - Elsevier
Down syndrome (DS) is the most common condition with intellectual disability and is caused
by trisomy of Homo sapiens chromosome 21 (HSA21). The increased dosage of genes on …
by trisomy of Homo sapiens chromosome 21 (HSA21). The increased dosage of genes on …
Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
Background Down syndrome (DS) individuals, by the age of 40s, are at increased risk to
develop Alzheimer-like dementia, with deposition in brain of senile plaques and …
develop Alzheimer-like dementia, with deposition in brain of senile plaques and …
Curcumin reduces cognitive deficits by inhibiting neuroinflammation through the endoplasmic reticulum stress pathway in apolipoprotein E4 transgenic mice
J Kou, M Wang, J Shi, H Zhang, X Pu, S Song… - ACS …, 2021 - ACS Publications
Apolipoprotein E4 (ApoE4) is the main genetic risk factor for Alzheimer's disease (AD), but
the exact way in which it causes AD remains unclear. Curcumin is considered to have good …
the exact way in which it causes AD remains unclear. Curcumin is considered to have good …
The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerative disorders
Protein homeostasis or “proteostasis” represent the process that regulates the balance of the
intracellular functional and “healthy” proteins. Proteostasis is fundamental to preserve …
intracellular functional and “healthy” proteins. Proteostasis is fundamental to preserve …
Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention
A major challenge in neurobiology is the identification of the mechanisms by which protein
misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant …
misfolding leads to cellular toxicity. Many neurodegenerative disorders, in which aberrant …
[HTML][HTML] Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies
Frontotemporal dementias (FTDs) encompass several disorders commonly characterized by
progressive frontotemporal lobar degeneration and dementia. Pathologically, TDP-43, FUS …
progressive frontotemporal lobar degeneration and dementia. Pathologically, TDP-43, FUS …
[HTML][HTML] Stress responses in down syndrome neurodegeneration: state of the art and therapeutic molecules
Down syndrome (DS) is the most common genomic disorder characterized by the increased
incidence of develo** early Alzheimer's disease (AD). In DS, the triplication of genes on …
incidence of develo** early Alzheimer's disease (AD). In DS, the triplication of genes on …