Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …

Cells undergo a major epigenome reconfiguration when reprogrammed to human induced
pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human …

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating
fundamental principles of embryonic pattern formation. Using single-cell genomic analysis …

Gastrulation is a fundamental and critical process of animal development whereby the mass
of cells that results from the proliferation of the zygote transforms itself into a recognizable …

During embryogenesis, organisms acquire their shape given boundary conditions that
impose geometrical, mechanical and biochemical constraints. A detailed integrative …

High-resolution maps of embryonic development suggest that acquisition of cell identity is
not limited to canonical germ layers but proceeds via alternative routes. Despite evidence …

Genetic differences between pluripotent stem cell lines cause variable activity of
extracellular signaling pathways, limiting reproducibility of directed differentiation protocols …

How cells build embryos is still a major mystery. Many unresolved questions require the
study of the processes that pattern and shape the embryo in live specimens, in toto, across …