Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …

Poultry such as chickens are valuable model animals not only in the food industry, but also
in developmental biology and biomedicine. Recently, precise genome-editing technologies …

Genomes can be edited by homologous recombination stimulated by CRISPR/Cas9
[clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated …

Gene-switch techniques hold promising applications in contemporary genetics research,
particularly in disease treatment and genetic engineering. Here, we developed a compact …

Rho promotes Rho-dependent termination (RDT) at the Rho-dependent terminator,
producing a variable-length region without secondary structure at the 3′ end of mRNA …

RNA editing is a prospective therapeutic approach for correcting harmful mutations, offering
the benefits of reversibility and tunability without permanently modifying the genome …

Alternative splicing allows multiple transcripts to be generated from the same gene to
diversify the protein repertoire and gain new functions despite a limited coding genome. It …

Genome editing is a powerful tool, enabling scientists to alter DNA sequence at virtually any
genome locus in any species. Different technologies have been developed employing …

The expression of therapeutic genes is critical for the efficacy of gene therapy products.
However, existing methods such as immunological analysis at the protein level or reverse …

The untranslated regions (UTRs) of mRNAs harbor regulatory elements influencing
translation efficiency. Although 3.7% of disease-relevant human mutations occur in UTRs …