Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance

RM Hassan, MS Abd El-Maksoud, IAY Ghannam… - European Journal of …, 2023 - Elsevier
The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …

Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa

SR Borgert, S Henke, F Witzgall, S Schmelz… - Nature …, 2022 - nature.com
Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to
severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three …

[HTML][HTML] Out of control: the need for standardised solvent approaches and data reporting in antibiofilm assays incorporating dimethyl-sulfoxide (DMSO)

K Summer, J Browne, M Hollanders, K Benkendorff - Biofilm, 2022 - Elsevier
Bacteria in biofilm formations are up to 1000 times less susceptible to antibiotics than their
planktonic counterparts. Recognition of the role of biofilms in∼ 80% of chronic infections …

Pan-vaccinomics approach towards a universal vaccine candidate against WHO priority pathogens to address growing global antibiotic resistance

S Ismail, F Shahid, A Khan, S Bhatti, S Ahmad… - Computers in Biology …, 2021 - Elsevier
Antimicrobial resistance (AMR) in bacterial pathogens is a major global distress. Due to the
slow progress of antibiotics development and the fast pace of resistance acquisition, there is …

Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy

VK Singh, M Almpani, D Maura, T Kitao… - Nature …, 2022 - nature.com
Intestinal barrier derangement allows intestinal bacteria and their products to translocate to
the systemic circulation. Pseudomonas aeruginosa (PA) superimposed infection in critically …

Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa

S Sabir, T Das, R Kuppusamy, TT Yu, MDP Willcox… - Bioorganic …, 2023 - Elsevier
It is well established that the quorum sensing (QS) in Pseudomonas aeruginosa is primarily
responsible for the synthesis and the release of several virulence factors including …

Halogenated Dihydropyrrol-2-One Molecules Inhibit Pyocyanin Biosynthesis by Blocking the Pseudomonas Quinolone Signaling System

T Das, S Sabir, R Chen, J Farrell, FH Kriel, GS Whiteley… - Molecules, 2022 - mdpi.com
Quorum-sensing (QS) systems of Pseudomonas aeruginosa are involved in the control of
biofilm formation and virulence factor production. The current study evaluated the ability of …

Novel quinoline‐based derivatives as the PqsR inhibitor against Pseudomonas aeruginosa PAO1

XH Huang, MT She, YH Zhang, YF Liu… - Journal of applied …, 2022 - academic.oup.com
Aims The emerging of drug resistant Pseudomonas aeruginosa is a critical challenge and
renders an urgent action to discover innovative antimicrobial interventions. One of these …

Novel seleno-and thio-urea containing dihydropyrrol-2-one analogues as antibacterial agents

S Sabir, TT Yu, R Kuppusamy, B Almohaywi… - Antibiotics, 2021 - mdpi.com
The quorum sensing (QS) system in multi-drug-resistant bacteria such as P. aeruginosa is
primarily responsible for the development of antibiotic resistance and is considered an …

[HTML][HTML] Synthesis of Novel Quinazolinone Analogues for Quorum Sensing Inhibition

S Shandil, TT Yu, S Sabir, DSC Black, N Kumar - Antibiotics, 2023 - mdpi.com
As bacteria continue to develop resistance mechanisms against antimicrobials, an
alternative method to tackle this global concern must be developed. As the pqs system is the …