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Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance
RM Hassan, MS Abd El-Maksoud, IAY Ghannam… - European Journal of …, 2023 - Elsevier
The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …
problem for the treatment of various infections. Biofilm formation in bacteria significantly …
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa
SR Borgert, S Henke, F Witzgall, S Schmelz… - Nature …, 2022 - nature.com
Pseudomonas aeruginosa is a major cause of nosocomial infections and also leads to
severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three …
severe exacerbations in cystic fibrosis or chronic obstructive pulmonary disease. Three …
[HTML][HTML] Out of control: the need for standardised solvent approaches and data reporting in antibiofilm assays incorporating dimethyl-sulfoxide (DMSO)
Bacteria in biofilm formations are up to 1000 times less susceptible to antibiotics than their
planktonic counterparts. Recognition of the role of biofilms in∼ 80% of chronic infections …
planktonic counterparts. Recognition of the role of biofilms in∼ 80% of chronic infections …
Pan-vaccinomics approach towards a universal vaccine candidate against WHO priority pathogens to address growing global antibiotic resistance
Antimicrobial resistance (AMR) in bacterial pathogens is a major global distress. Due to the
slow progress of antibiotics development and the fast pace of resistance acquisition, there is …
slow progress of antibiotics development and the fast pace of resistance acquisition, there is …
Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy
Intestinal barrier derangement allows intestinal bacteria and their products to translocate to
the systemic circulation. Pseudomonas aeruginosa (PA) superimposed infection in critically …
the systemic circulation. Pseudomonas aeruginosa (PA) superimposed infection in critically …
Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa
It is well established that the quorum sensing (QS) in Pseudomonas aeruginosa is primarily
responsible for the synthesis and the release of several virulence factors including …
responsible for the synthesis and the release of several virulence factors including …
Halogenated Dihydropyrrol-2-One Molecules Inhibit Pyocyanin Biosynthesis by Blocking the Pseudomonas Quinolone Signaling System
Quorum-sensing (QS) systems of Pseudomonas aeruginosa are involved in the control of
biofilm formation and virulence factor production. The current study evaluated the ability of …
biofilm formation and virulence factor production. The current study evaluated the ability of …
Novel quinoline‐based derivatives as the PqsR inhibitor against Pseudomonas aeruginosa PAO1
XH Huang, MT She, YH Zhang, YF Liu… - Journal of applied …, 2022 - academic.oup.com
Aims The emerging of drug resistant Pseudomonas aeruginosa is a critical challenge and
renders an urgent action to discover innovative antimicrobial interventions. One of these …
renders an urgent action to discover innovative antimicrobial interventions. One of these …
Novel seleno-and thio-urea containing dihydropyrrol-2-one analogues as antibacterial agents
The quorum sensing (QS) system in multi-drug-resistant bacteria such as P. aeruginosa is
primarily responsible for the development of antibiotic resistance and is considered an …
primarily responsible for the development of antibiotic resistance and is considered an …
[HTML][HTML] Synthesis of Novel Quinazolinone Analogues for Quorum Sensing Inhibition
As bacteria continue to develop resistance mechanisms against antimicrobials, an
alternative method to tackle this global concern must be developed. As the pqs system is the …
alternative method to tackle this global concern must be developed. As the pqs system is the …