Post‐traumatic osteoarthritis of the ankle: a distinct clinical entity requiring new research approaches

ML Delco, JG Kennedy, LJ Bonassar… - Journal of Orthopaedic …, 2017 - Wiley Online Library
The diagnosis of ankle osteoarthritis (OA) is increasing as a result of advancements in non‐
invasive imaging modalities such as magnetic resonance imaging, improved arthroscopic …

A systematic review and guide to mechanical testing for articular cartilage tissue engineering

JM Patel, BC Wise, ED Bonnevie… - Tissue Engineering Part …, 2019 - liebertpub.com
Articular cartilage is integral to the mechanical function of many joints in the body. When
injured, cartilage lacks the capacity to self-heal, and thus, therapies and replacements have …

Cartilage tissue engineering in practice: preclinical trials, clinical applications, and prospects

Z Zhang, Y Mu, H Zhou, H Yao… - Tissue Engineering Part B …, 2023 - liebertpub.com
Articular cartilage defects significantly compromise the quality of life in the global population.
Although many strategies are needed to repair articular cartilage, including microfracture …

Structure-function relations and rigidity percolation in the shear properties of articular cartilage

JL Silverberg, AR Barrett, M Das, PB Petersen… - Biophysical journal, 2014 - cell.com
Among mammalian soft tissues, articular cartilage is particularly interesting because it can
endure a lifetime of daily mechanical loading despite having minimal regenerative capacity …

Measuring microscale strain fields in articular cartilage during rapid impact reveals thresholds for chondrocyte death and a protective role for the superficial layer

LR Bartell, LA Fortier, LJ Bonassar, I Cohen - Journal of biomechanics, 2015 - Elsevier
Articular cartilage is a heterogeneous soft tissue that dissipates and distributes loads in
mammalian joints. Though robust, cartilage is susceptible to damage from loading at high …

Effects of enzymatic treatments on the depth‐dependent viscoelastic shear properties of articular cartilage

DJ Griffin, J Vicari, MR Buckley… - Journal of …, 2014 - Wiley Online Library
Osteoarthritis (OA) is a disease that involves the erosion and structural weakening of
articular cartilage. OA is characterized by the degradation of collagen and proteoglycans in …

Mitoprotective therapy prevents rapid, strain‐dependent mitochondrial dysfunction after articular cartilage injury

LR Bartell, LA Fortier, LJ Bonassar… - Journal of …, 2020 - Wiley Online Library
Posttraumatic osteoarthritis (PTOA) involves the mechanical and biological deterioration of
articular cartilage that occurs following joint injury. PTOA is a growing problem in health care …

Stabilized formulation for phase‐field fracture in nearly incompressible hyperelasticity

I Ang, N Bouklas, B Li - International Journal for Numerical …, 2022 - Wiley Online Library
This work presents a stabilized formulation for phase‐field fracture of hyperelastic materials
near the limit of incompressibility. At this limit, traditional mixed displacement and pressure …

Physiology and engineering of the graded interfaces of musculoskeletal junctions

ED Bonnevie, RL Mauck - Annual review of biomedical …, 2018 - annualreviews.org
The connective tissues of the musculoskeletal system can be grouped into fibrous,
cartilaginous, and calcified tissues. While each tissue type has a distinct composition and …

Critical review on the physical and mechanical factors involved in tissue engineering of cartilage

C Gaut, K Sugaya - Regenerative medicine, 2015 - Taylor & Francis
Articular cartilage defects often progress to osteoarthritis, which negatively impacts quality of
life for millions of people worldwide and leads to high healthcare expenditures. Tissue …