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Metal–organic framework-based enzyme biocomposites
Because of their efficiency, selectivity, and environmental sustainability, there are significant
opportunities for enzymes in chemical synthesis and biotechnology. However, as the three …
opportunities for enzymes in chemical synthesis and biotechnology. However, as the three …
Enzyme–MOF (metal–organic framework) composites
The ex vivo application of enzymes in various processes, especially via enzyme
immobilization techniques, has been extensively studied in recent years in order to enhance …
immobilization techniques, has been extensively studied in recent years in order to enhance …
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity
α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased
in Lewy body disease, such as Parkinson's disease (PD) and dementia with Lewy bodies …
in Lewy body disease, such as Parkinson's disease (PD) and dementia with Lewy bodies …
Molecular interactions underlying liquid− liquid phase separation of the FUS low-complexity domain
The low-complexity domain of the RNA-binding protein FUS (FUS LC) mediates liquid−
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Membrane encapsulation is frequently used by the cell to sequester biomolecules and
compartmentalize their function. Cells also concentrate molecules into phase-separated …
compartmentalize their function. Cells also concentrate molecules into phase-separated …
Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles
Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form …
interactions. In addition to membrane-encapsulated compartments, cells can form …
Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules
Enhancing the robustness of functional biomacromolecules is a critical challenge in
biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical …
biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical …
[HTML][HTML] Towards applications of bioentities@ MOFs in biomedicine
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells
have emerged as novel biocomposites for application to drug delivery, biosensing …
have emerged as novel biocomposites for application to drug delivery, biosensing …
[HTML][HTML] A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins
AG Kikhney, DI Svergun - FEBS letters, 2015 - Elsevier
Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation
Summary hnRNPA2, a component of RNA-processing membraneless organelles, forms
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
inclusions when mutated in a syndrome characterized by the degeneration of neurons …