Metal–organic framework-based enzyme biocomposites

W Liang, P Wied, F Carraro, CJ Sumby… - Chemical …, 2021 - ACS Publications
Because of their efficiency, selectivity, and environmental sustainability, there are significant
opportunities for enzymes in chemical synthesis and biotechnology. However, as the three …

Enzyme–MOF (metal–organic framework) composites

X Lian, Y Fang, E Joseph, Q Wang, J Li… - Chemical Society …, 2017 - pubs.rsc.org
The ex vivo application of enzymes in various processes, especially via enzyme
immobilization techniques, has been extensively studied in recent years in order to enhance …

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

SS Ghanem, NK Majbour, NN Vaikath… - Proceedings of the …, 2022 - pnas.org
α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased
in Lewy body disease, such as Parkinson's disease (PD) and dementia with Lewy bodies …

Molecular interactions underlying liquid− liquid phase separation of the FUS low-complexity domain

AC Murthy, GL Dignon, Y Kan, GH Zerze… - Nature structural & …, 2019 - nature.com
The low-complexity domain of the RNA-binding protein FUS (FUS LC) mediates liquid−
liquid phase separation (LLPS), but the interactions between the repetitive SYGQ-rich …

Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation

JP Brady, PJ Farber, A Sekhar, YH Lin… - Proceedings of the …, 2017 - pnas.org
Membrane encapsulation is frequently used by the cell to sequester biomolecules and
compartmentalize their function. Cells also concentrate molecules into phase-separated …

Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles

TJ Nott, E Petsalaki, P Farber, D Jervis, E Fussner… - Molecular cell, 2015 - cell.com
Cells chemically isolate molecules in compartments to both facilitate and regulate their
interactions. In addition to membrane-encapsulated compartments, cells can form …

Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules

K Liang, R Ricco, CM Doherty, MJ Styles, S Bell… - Nature …, 2015 - nature.com
Enhancing the robustness of functional biomacromolecules is a critical challenge in
biotechnology, which if addressed would enhance their use in pharmaceuticals, chemical …

[HTML][HTML] Towards applications of bioentities@ MOFs in biomedicine

MJ Velásquez-Hernández, M Linares-Moreau… - Coordination Chemistry …, 2021 - Elsevier
Metal–organic frameworks (MOFs) combined with biomacromolecules, viruses and cells
have emerged as novel biocomposites for application to drug delivery, biosensing …

[HTML][HTML] A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins

AG Kikhney, DI Svergun - FEBS letters, 2015 - Elsevier
Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …

Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation

VH Ryan, GL Dignon, GH Zerze, CV Chabata, R Silva… - Molecular cell, 2018 - cell.com
Summary hnRNPA2, a component of RNA-processing membraneless organelles, forms
inclusions when mutated in a syndrome characterized by the degeneration of neurons …