Drug-tolerant persister cells (persisters) evade apoptosis upon targeted and conventional
cancer therapies and represent a major non-genetic barrier to effective cancer treatment …

Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver
disease worldwide and the anticipated health burden is huge. There are limited therapeutic …

We sought to identify factors that are predictive of liver transplantation or death in patients
with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous …

Radiation therapy (RT) in combination with an immune checkpoint inhibitor (ICI) represents
a promising regimen for non-small cell lung cancer (NSCLC); however, the underlying …

Adipocyte death occurs under various physiopathological conditions, including obesity and
alcohol drinking, and can trigger organ damage particularly in the liver, but the underlying …

Paediatric high‐grade gliomas (pHGG) represent a therapeutically challenging group of
tumors. Despite decades of research, there has been minimal improvement in treatment and …

Intrapancreatic trypsin activation by dysregulated macroautophagy/autophagy and
pathological exocytosis of zymogen granules (ZGs), along with activation of inhibitor of …

Chronic Cd exposure induces an inflammatory response that contributes to liver damage. In
the present study, C57BL/6 J mice (8 weeks) were administered CdCl 2 (0.6 mg/L) orally for …

SNARE-mediated membrane fusion plays a crucial role in presynaptic vesicle exocytosis
and also in postsynaptic receptor delivery. The latter is considered particularly important for …

SNARE-mediated vesicular transport is thought to play roles in photoreceptor glutamate
exocytosis and photopigment delivery. However, the functions of Synaptosomal-associated …