Seizure prediction—ready for a new era

L Kuhlmann, K Lehnertz, MP Richardson… - Nature Reviews …, 2018 - nature.com
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

[HTML][HTML] Chemically complex intermetallic alloys: A new frontier for innovative structural materials

T Yang, BX Cao, TL Zhang, YL Zhao, WH Liu, HJ Kong… - Materials today, 2022 - Elsevier
Intermetallic materials are bestowed by diverse ordered superlattice structures together with
many unusual properties. In particular, the advent of chemically complex intermetallic alloys …

Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy

AN Khambhati, A Shafi, VR Rao… - Science Translational …, 2021 - science.org
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …

Metastable brain waves

JA Roberts, LL Gollo, RG Abeysuriya, G Roberts… - Nature …, 2019 - nature.com
Traveling patterns of neuronal activity—brain waves—have been observed across a breadth
of neuronal recordings, states of awareness, and species, but their emergence in the human …

Dissociation of broadband high-frequency activity and neuronal firing in the neocortex

M Leszczyński, A Barczak, Y Kajikawa, I Ulbert… - Science …, 2020 - science.org
Broadband high-frequency activity (BHA; 70 to 150 Hz), also known as “high gamma,” a key
analytic signal in human intracranial (electrocorticographic) recordings, is often assumed to …

Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy

T Proix, VK Jirsa, F Bartolomei, M Guye… - Nature …, 2018 - nature.com
Recent studies have shown that seizures can spread and terminate across brain areas via a
rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset …

Widespread temporal coding of cognitive control in the human prefrontal cortex

EH Smith, G Horga, MJ Yates, CB Mikell… - Nature …, 2019 - nature.com
When making decisions we often face the need to adjudicate between conflicting strategies
or courses of action. Our ability to understand the neuronal processes underlying conflict …

A model for focal seizure onset, propagation, evolution, and progression

J Liou, EH Smith, LM Bateman, SL Bruce… - Elife, 2020 - elifesciences.org
We developed a neural network model that can account for major elements common to
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …

Human seizures couple across spatial scales through travelling wave dynamics

LE Martinet, G Fiddyment, JR Madsen… - Nature …, 2017 - nature.com
Epilepsy—the propensity toward recurrent, unprovoked seizures—is a devastating disease
affecting 65 million people worldwide. Understanding and treating this disease remains a …

Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges

EH Smith, J Liou, EM Merricks, T Davis, K Thomson… - Elife, 2022 - elifesciences.org
Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large
intermittent electrophysiological events observed between seizures in patients with epilepsy …