Seizure prediction—ready for a new era
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …
majority of people with epilepsy regard the unpredictability of seizures as a major issue …
[HTML][HTML] Chemically complex intermetallic alloys: A new frontier for innovative structural materials
Intermetallic materials are bestowed by diverse ordered superlattice structures together with
many unusual properties. In particular, the advent of chemically complex intermetallic alloys …
many unusual properties. In particular, the advent of chemically complex intermetallic alloys …
Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …
Metastable brain waves
Traveling patterns of neuronal activity—brain waves—have been observed across a breadth
of neuronal recordings, states of awareness, and species, but their emergence in the human …
of neuronal recordings, states of awareness, and species, but their emergence in the human …
Dissociation of broadband high-frequency activity and neuronal firing in the neocortex
Broadband high-frequency activity (BHA; 70 to 150 Hz), also known as “high gamma,” a key
analytic signal in human intracranial (electrocorticographic) recordings, is often assumed to …
analytic signal in human intracranial (electrocorticographic) recordings, is often assumed to …
Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy
Recent studies have shown that seizures can spread and terminate across brain areas via a
rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset …
rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset …
Widespread temporal coding of cognitive control in the human prefrontal cortex
When making decisions we often face the need to adjudicate between conflicting strategies
or courses of action. Our ability to understand the neuronal processes underlying conflict …
or courses of action. Our ability to understand the neuronal processes underlying conflict …
A model for focal seizure onset, propagation, evolution, and progression
We developed a neural network model that can account for major elements common to
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …
Human seizures couple across spatial scales through travelling wave dynamics
Epilepsy—the propensity toward recurrent, unprovoked seizures—is a devastating disease
affecting 65 million people worldwide. Understanding and treating this disease remains a …
affecting 65 million people worldwide. Understanding and treating this disease remains a …
Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges
Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large
intermittent electrophysiological events observed between seizures in patients with epilepsy …
intermittent electrophysiological events observed between seizures in patients with epilepsy …