The biomedical research community addresses reproducibility challenges in animal studies
through standardized nomenclature, improved experimental design, transparent reporting …

Enduring chromosome segregation errors represent potential threats to genomic stability
due to eventual chromosome copy number alterations (aneuploidy) and formation of …

Background Structural variation (SV) influences genome organization and contributes to
human disease. However, the complete mutational spectrum of SV has not been routinely …

Over the last decade, new types of massive and complex chromosomal rearrangements
based on the chaotic shattering and restructuring of chromosomes have been identified in …

Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one
or few chromosomes in multiple fragments and consequent random rejoining and repair …

Designated under the name of chromoanagenesis, the phenomena of chromothripsis,
chromanasynthesis and chromoplexy constitute new types of complex rearrangements …

In the present review, we focus on the phenomenon of chromothripsis, a new type of
complex chromosomal rearrangements. We discuss the challenges of chromothripsis …

The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects,
regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its …

Background During the last decade, genome sequencing projects in cancer genomes as
well as in patients with congenital diseases and healthy individuals have led to the …

Chromoanagenesis is a single catastrophic event that involves, in most cases, localized
chromosomal shattering and reorganization, resulting in a dramatically restructured …