The druggable genome is limited by structural features that can be targeted by small
molecules in disease-relevant proteins. While orthosteric and allosteric protein modulators …

There is growing evidence that lactate can have a wide range of biological impacts in
addition to being a waste product of metabolism. Because of the Warburg effect, tumors …

KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress
responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the …

The pyruvate kinase M2 (PKM2) can significantly affect the differentiation of Th17 and Treg
cells; thus, it is considered a promising target for UC therapy. Herein, five series of …

Background Therapeutic approaches based on glycolysis and energy metabolism of tumor
cells are new promising strategies for the treatment of cancer. Currently, researches on the …

Natural products serve as a valuable reservoir of anticancer agents. Chinese poplar propolis
(CP) has exhibited remarkable antitumor activities, yet its precise mechanisms of action …

This rational pursuit led to the identification of a novel sulfonamide derivative as a potent anti-
lung cancer (LC) compound. Considering these results, we synthesized 38 novel …

Thienopyrimidines are an emerging class of fused pyrimidines due to their broad spectrum
of pharmacological properties, including antimicrobial, anti-inflammatory, antimalarial …

Abstract Pyruvate kinase M2 (PKM2) is a key glycolytic enzyme that regulates proliferating
cell metabolism. The role of PKM2 in common diseases has been well established, but its …

Aerobic glycolysis is a metabolic reprogramming of tumor cells that is essential for
sustaining their phenotype of fast multiplication by continuously supplying energy and mass …