Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

The calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein
phosphorylation and calcium signaling cascades, where it provides an essential nodal point …

BACKGROUND Dapagliflozin (DAPA) is an inhibitor of sodium-glucose cotransporter 2
prescribed for type 2 diabetes mellitus. DAPA plays a protective role against cardiovascular …

Accumulated pieces of evidence have proved the beneficial effects of melatonin on
myocardial ischemia/reperfusion (MI/R) injury, and these effects were largely dependent on …

The Ras family of small Guanosine Triphosphate (GTP)-binding proteins (G proteins)
represents one of the main components of intracellular signal transduction required for …

Although pathological cardiac hypertrophy represents a leading cause of morbidity and
mortality worldwide, our understanding of the molecular mechanisms underlying this …

Calcineurin, also known as PP2B or PPP3, is a member of the PPP family of protein
phosphatases that also includes PP1 and PP2A. Together these three phosphatases …

Pulmonary arterial hypertension (PAH) is a devastating lung disease characterized by the
progressive obstruction of the distal pulmonary arteries (PA). Structural and functional …

Abstract Dual-specificity phosphatase 14 (Dusp14), an important negative modulator of
mitogen-activated protein kinase (MAPK) signaling pathways, has been implicated in …

Mitochondrial calcium uptake 1 (MICU1) is a pivotal molecule in maintaining mitochondrial
homeostasis under stress conditions. However, it is unclear whether MICU1 attenuates …