Molecular bottlebrush prodrugs as mono-and triplex combination therapies for multiple myeloma

A Detappe, HVT Nguyen, Y Jiang, MP Agius… - Nature …, 2023 - nature.com
Cancer therapies often have narrow therapeutic indexes and involve potentially suboptimal
combinations due to the dissimilar physical properties of drug molecules. Nanomedicine …

From macromonomers to bottlebrush copolymers with sequence control: synthesis, properties, and applications

KH Kim, J Nam, J Choi, M Seo, J Bang - Polymer Chemistry, 2022 - pubs.rsc.org
Bottlebrush polymers (BBPs) are a type of comb-like macromolecule with densely grafted
polymeric sidechains attached to the polymer backbones, and many intriguing properties …

[HTML][HTML] Grubbs' and Schrock's catalysts, ring opening metathesis polymerization and molecular brushes—synthesis, characterization, properties and applications

I Choinopoulos - Polymers, 2019 - mdpi.com
In this review, molecular brushes and other macromolecular architectures bearing a
bottlebrush segment where the main chain is synthesized by ring opening metathesis …

Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation

SH Bhagchandani, F Vohidov, LE Milling, EY Tong… - Science …, 2023 - science.org
Imidazoquinolines (IMDs), such as resiquimod (R848), are of great interest as potential
cancer immunotherapies because of their ability to activate Toll-like receptor 7 (TLR7) …

Complex polymer architectures using ring-opening metathesis polymerization: synthesis, applications, and practical considerations

SE Blosch, SJ Scannelli, M Alaboalirat… - Macromolecules, 2022 - ACS Publications
Nature shows us that complex molecular architectures lead to unique material properties,
and these observations have driven polymer scientists to synthesize complex architectures …

Materials design of highly branched bottlebrush polymers at the intersection of modeling, synthesis, processing, and characterization

T Pan, S Dutta, Y Kamble, BB Patel… - Chemistry of …, 2022 - ACS Publications
Highly branched “bottlebrush” polymers are a class of macromolecules characterized by
side chains that are densely grafted from a backbone that is typically linear. Their unique …

Catalytic living ring-opening metathesis polymerization with Grubbs' second-and third-generation catalysts

M Yasir, P Liu, IK Tennie, AFM Kilbinger - Nature chemistry, 2019 - nature.com
In a conventional living ring-opening metathesis polymerization (ROMP), an equal number
of ruthenium complexes to the number of polymer chains synthesized are required. This can …

Polyoxazoline-based bottlebrush and brush-arm star polymers via ROMP: syntheses and applications as organic radical contrast agents

GG Alvaradejo, HVT Nguyen, P Harvey… - ACS macro …, 2019 - ACS Publications
The synthesis of functional poly (2-alkyl-2-oxazoline)(PAOx) copolymers with complex
nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) …

Triply loaded nitroxide brush-arm star polymers enable metal-free millimetric tumor detection by magnetic resonance imaging

HVT Nguyen, A Detappe, NM Gallagher, H Zhang… - ACS …, 2018 - ACS Publications
Nitroxides occupy a privileged position among plausible metal-free magnetic resonance
imaging (MRI) contrast agents (CAs) due to their inherently low-toxicity profiles; …

Tailoring the Architecture of Molecular Bottlebrushes via Click Grafting‐Onto Strategy

Y Shi, W Hou, Z Li, Y Chen - Macromolecular Rapid …, 2023 - Wiley Online Library
Molecular bottlebrush (MBB) refer to a synthetic macromolecule, in which a mass of
polymeric side chains (SCs) are covalently connected to a macromolecular backbone …