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Drug repositioning: Progress and challenges in drug discovery for various diseases
Compared with traditional de novo drug discovery, drug repurposing has become an
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …
attractive drug discovery strategy due to its low-cost and high efficiency. Through a …
[HTML][HTML] Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation
Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential
process for mammalian cell survival. An enzyme responsible for this process, sodium …
process for mammalian cell survival. An enzyme responsible for this process, sodium …
[HTML][HTML] Unveiling the anti-cancer mechanisms of calotropin: Insights into cell growth inhibition, cell cycle arrest, and metabolic regulation in human oral squamous …
Background Calotropin, a cardiac glycoside obtained from the plant Calotropis gigantea,
has demonstrated promising potential as an anti-tumorigenesis compound. Objective The …
has demonstrated promising potential as an anti-tumorigenesis compound. Objective The …
Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity
W Huang, Y He, R Jiang, Z Deng, F Long - Acs Catalysis, 2022 - ACS Publications
Cardiotonic steroids (CTSs) are ancient and effective clinical drugs for treating heart failure.
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …
[HTML][HTML] Emergence of cardiac glycosides as potential drugs: Current and future scope for cancer therapeutics
Cardiac glycosides are natural sterols and constitute a group of secondary metabolites
isolated from plants and animals. These cardiotonic agents are well recognized and …
isolated from plants and animals. These cardiotonic agents are well recognized and …
Cardiac glycosides as immune system modulators
Cardiac glycosides (CGs) are natural steroid compounds occurring both in plants and
animals. They are known for long as cardiotonic agents commonly used for various cardiac …
animals. They are known for long as cardiotonic agents commonly used for various cardiac …
Na+/K+-ATPase: More than an Electrogenic Pump
The sodium pump, or Na+/K+-ATPase (NKA), is an essential enzyme found in the plasma
membrane of all animal cells. Its primary role is to transport sodium (Na+) and potassium …
membrane of all animal cells. Its primary role is to transport sodium (Na+) and potassium …
Prospects of compounds of herbal plants as anticancer agents: a comprehensive review from molecular pathways
Cancer refers to the proliferation and multiplication of aberrant cells inside the human body,
characterized by their capacity to proliferate and infiltrate various anatomical regions …
characterized by their capacity to proliferate and infiltrate various anatomical regions …
Digoxin and its Na+/K+-ATPase-targeted actions on cardiovascular diseases and cancer
Abstract Na+/K+-ATPase (NKA) is a plasma membrane ion-transporting protein involved in
the generation and maintenance of Na+ and K+ gradients across the cell membrane, which …
the generation and maintenance of Na+ and K+ gradients across the cell membrane, which …
The mechanistic role of cardiac glycosides in DNA damage response and repair signaling
Cardiac glycosides (CGs) are a class of bioactive organic compounds well-known for their
application in treating heart disease despite a narrow therapeutic window. Considerable …
application in treating heart disease despite a narrow therapeutic window. Considerable …