[HTML][HTML] Advances and prospects of RNA delivery nanoplatforms for cancer therapy
Modern oncology is experiencing significant changes with the recent advances in RNA-
based therapeutics. As new emerging cutting-edge technology, mRNA vaccines hold …
based therapeutics. As new emerging cutting-edge technology, mRNA vaccines hold …
Mitigated Cytotoxicity and Tremendously Enhanced Gene Transfection Efficiency of PEI through Facile One‐Step Carbamate Modification
Chuan Yang, Wei Cheng, Pei Yun Teo, Amanda C. Engler, Daniel J. Coady, James L.
Hedrick,* and Yi Yan Yang* disulphide bond, via the primary amines of PEI to facilitate …
Hedrick,* and Yi Yan Yang* disulphide bond, via the primary amines of PEI to facilitate …
Lipid nanocapsules functionalized with polyethyleneimine for plasmid DNA and drug co-delivery and cell imaging
The paper reports on the preparation of lipid nanocapsules (LNCs) functionalized with poly
(ethyleneimine)(PEI) moieties and their successful use as drug and gene delivery systems …
(ethyleneimine)(PEI) moieties and their successful use as drug and gene delivery systems …
Selective blocking of primary amines in branched polyethylenimine with biocompatible ligand alleviates cytotoxicity and augments gene delivery efficacy in …
Recently, polyethylenimines (PEIs) have emerged as efficient vectors for nucleic acids
delivery. However, inherent cytotoxicity has limited their in vivo applications. To address this …
delivery. However, inherent cytotoxicity has limited their in vivo applications. To address this …
Delivery of a granzyme B inhibitor gene using carbamate-mannose modified PEI protects against cytotoxic lymphocyte killing
Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells protect vertebrates by killing
infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB …
infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB …
Amino acid-modified polyethylenimines with enhanced gene delivery efficiency and biocompatibility
QF Zhang, CR Luan, DX Yin, J Zhang, YH Liu, Q Peng… - Polymers, 2015 - mdpi.com
The development of gene delivery vectors with high efficiency and biocompatibility is one of
the key points of gene therapy. A series of polycations were prepared from polyethylenimine …
the key points of gene therapy. A series of polycations were prepared from polyethylenimine …
Biodegradable and versatile polyethylenimine derivatives efficiently transfer DNA and siRNA into mammalian cells
Polyethylenimines (PEIs) are considered as the most promising vectors for non-viral gene
delivery applications. Here, we report the synthesis and in vitro evaluation of two non-toxic …
delivery applications. Here, we report the synthesis and in vitro evaluation of two non-toxic …
Amphiphilic azobenzene-neomycin conjugate self-assembles into nanostructures and transports plasmid DNA efficiently into the mammalian cells
S Yadav, SR Deka, D Jha, HK Gautam… - Colloids and Surfaces B …, 2016 - Elsevier
The present study demonstrates the use of self-assembled nanostructures of cationic
amphiphilic azobenzene-neomycin (a small molecule) conjugate, Azo-Neo, as delivery …
amphiphilic azobenzene-neomycin (a small molecule) conjugate, Azo-Neo, as delivery …
Self-assembled amphiphilic phosphopyridoxyl-polyethylenimine polymers exhibit high cell viability and gene transfection efficiency in vitro and in vivo
Branched polyethylenimine (bPEI) was conjugated with hydrophobic pyridoxal phosphate
(PLP) in the side chain via reaction with primary amines to obtain amphiphilic …
(PLP) in the side chain via reaction with primary amines to obtain amphiphilic …
Harnessing the gene delivery, anti-cancer and antimicrobial potential of polyethylene biguanides and their nanotized forms
S Yadav, D Jha, HK Gautam, P Kumar - Journal of Polymer Research, 2022 - Springer
Abstract Here, linear polyethylenimines (lPEI, 2.5 and 25 kDa) and their nanoparticles
(prepared via reaction with a crosslinker, 1, 4-butanediol diglycidyl ether) have been reacted …
(prepared via reaction with a crosslinker, 1, 4-butanediol diglycidyl ether) have been reacted …