Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …

Microfluidics provides a great opportunity to create devices capable of outperforming
classical techniques in biomedical and chemical research. In this review, the origins of this …

Single-cell RNA sequencing has recently emerged as a powerful tool for map** cellular
heterogeneity in diseased and healthy tissues, yet high-throughput methods are needed for …

Droplet-based microfluidic systems have been employed to manipulate discrete fluid
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …

Significant breakthroughs have been made in digital microfluidic (DMF)-based technologies
over the past decades. DMF technology has attracted great interest in bioassays depending …

Metabolic engineering aims to develop efficient cell factories by rewiring cellular
metabolism. As one of the most commonly used cell factories, Saccharomyces cerevisiae …

There is a recognized and growing need for rapid and efficient cell assays, where the size of
microfluidic devices lend themselves to the manipulation of cellular populations down to the …

The ability to manipulate and sort droplets is a fundamental issue in droplet-based
microfluidics. Various lab-on-a-chip applications can only be realized if droplets are …

Ultrahigh-throughput screening, in which members of enzyme libraries compartmentalized
in water-in-oil emulsion droplets are assayed, has emerged as a powerful format for directed …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …