HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination

C Evans, CE Jones, AJ Prendergast - The Lancet infectious diseases, 2016 - thelancet.com
The number of infants infected with HIV is declining with the rise in interventions for the
elimination of paediatric HIV infection, but the number of uninfected infants exposed to HIV …

The role of environmental factors in modulating immune responses in early life

DM MacGillivray, TR Kollmann - Frontiers in immunology, 2014 - frontiersin.org
The concept of immunological memory stipulates that past exposures shape present
immune function. These exposures include not only specific antigens impacting adaptive …

HIV-exposed uninfected children: a growing population with a vulnerable immune system?

L Afran, M Garcia Knight, E Nduati… - Clinical & …, 2014 - academic.oup.com
Through the successful implementation of policies to prevent mother-to-child-transmission
(PMTCT) of HIV-1 infection, children born to HIV-1-infected mothers are now much less likely …

Training the fetal immune system through maternal inflammation—a layered hygiene hypothesis

AC Apostol, KDC Jensen, AE Beaudin - Frontiers in immunology, 2020 - frontiersin.org
Over the last century, the alarming surge in allergy and autoimmune disease has led to the
hypothesis that decreasing exposure to microbes, which has accompanied industrialization …

Vaccine responses in newborns

A Saso, B Kampmann - Seminars in immunopathology, 2017 - Springer
Immunisation of the newborn represents a key global strategy in overcoming morbidity and
mortality due to infection in early life. Potential limitations, however, include poor …

The immune system of HIV-exposed uninfected infants

B Abu-Raya, TR Kollmann, A Marchant… - Frontiers in …, 2016 - frontiersin.org
Infants born to human immunodeficiency virus (HIV) infected women are HIV-exposed but
the majority remains uninfected [ie, HIV-exposed uninfected (HEU)]. HEU infants suffer …

Immunology of pediatric HIV infection

NH Tobin, GM Aldrovandi - Immunological reviews, 2013 - Wiley Online Library
Most infants born to human immunodeficiency virus (HIV)‐infected women escape HIV
infection. Infants evade infection despite an immature immune system and, in the case of …

Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections

N Dauby, T Goetghebuer, TR Kollmann… - The Lancet infectious …, 2012 - thelancet.com
Chronic infections during pregnancy are highly prevalent in some parts of the world.
Infections with helminths, Trypanosoma cruzi, Plasmodium spp, and HIV might affect the …

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical …

H Mataramvura, MJ Bunders, K Duri - Frontiers in immunology, 2023 - frontiersin.org
Commencing lifelong antiretroviral therapy (ART) immediately following HIV diagnosis
(Option B+) has dramatically improved the health of HIV-infected women and their children …

Increased risk of serious bacterial infections due to maternal immunosuppression in HIV-exposed uninfected infants in a European country

C Taron-Brocard, J Le Chenadec, A Faye… - Clinical Infectious …, 2014 - academic.oup.com
Background. Morbidity and mortality are higher among human immunodeficiency virus (HIV)
exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had …