Amyloid toxicity in Alzheimer's disease
A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …
Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
dementia and memory loss for which no cure or effective prevention is currently available …
dementia and memory loss for which no cure or effective prevention is currently available …
Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy
The ability of amyloid-β peptide (Aβ) to disrupt membrane integrity and cellular homeostasis
is believed to be central to Alzheimer's disease pathology. Aβ is reported to have various …
is believed to be central to Alzheimer's disease pathology. Aβ is reported to have various …
Preparation of DOPC and DPPC supported planar lipid bilayers for atomic force microscopy and atomic force spectroscopy
Cell membranes are typically very complex, consisting of a multitude of different lipids and
proteins. Supported lipid bilayers are widely used as model systems to study biological …
proteins. Supported lipid bilayers are widely used as model systems to study biological …
[HTML][HTML] Effect of melatonin and cholesterol on the structure of DOPC and DPPC membranes
The cell membrane plays an important role in the molecular mechanism of amyloid toxicity
associated with Alzheimer's disease. The membrane's chemical composition and the …
associated with Alzheimer's disease. The membrane's chemical composition and the …
3D-visualization of amyloid-β oligomer interactions with lipid membranes by cryo-electron tomography
Amyloid-β (Aβ) assemblies have been shown to bind to lipid bilayers. This can disrupt
membrane integrity and cause a loss of cellular homeostasis, that triggers a cascade of …
membrane integrity and cause a loss of cellular homeostasis, that triggers a cascade of …
Atomic force microscopy and other scanning probe microscopy methods to study nanoscale domains in model lipid membranes
M Robinson, CT Filice, DM McRae… - Advances in Physics …, 2023 - Taylor & Francis
The cell membrane is a fundamental biological structure, which is only 6–10 nm thick. It is
composed of hundreds of lipid types, which form small and dynamic lipid domains or rafts …
composed of hundreds of lipid types, which form small and dynamic lipid domains or rafts …
Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons
Small soluble species of amyloid-beta (Aβ) formed during early peptide aggregation stages
are responsible for several neurotoxic mechanisms relevant to the pathology of Alzheimer's …
are responsible for several neurotoxic mechanisms relevant to the pathology of Alzheimer's …
Membrane domain modulation of Aβ 1–42 oligomer interactions with supported lipid bilayers: an atomic force microscopy investigation
Alzheimer's disease is a devastating pathology affecting an increasing number of individuals
following the general rise in life expectancy. Amyloid peptide Aβ1–42 has been identified as …
following the general rise in life expectancy. Amyloid peptide Aβ1–42 has been identified as …
Quartz crystal microbalance and atomic force microscopy to characterize mimetic systems based on supported lipids bilayer
NF Bonet, DG Cava, M Vélez - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Quartz Crystal Microbalance (QCM) with dissipation and Atomic Force Microscopy (AFM) are
two characterization techniques that allow describing processes taking place at solid-liquid …
two characterization techniques that allow describing processes taking place at solid-liquid …