Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …

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Numerous studies have contributed to the development of natural and synthetic
antimicrobial peptides as a prospective source of antibiotic agents. Based on the concept …

The discovery of small molecules that bind to a specific target and disrupt the function of
proteins is an important step in chemical biology, especially for poorly characterized …

Small-molecule inhibitors can accelerate the functional annotation and validate the
therapeutic potential of proteins implicated in disease. Phenotypic screens provide an …

Herein we report the expanded functional group compatibility of small-molecule microarrays
to include immobilization of primary alcohols, secondary alcohols, phenols, carboxylic acids …

The year 2004 represents a milestone for the biosensor research community: in this year,
over 1000 articles were published describing experiments performed using commercially …

Directed or exploratory drug development programs constantly seek robust screening
platforms for the high fidelity identification and validation of potential targets. Small-molecule …

The amyloid-β (Aβ) aggregation pathway is a key target in efforts to discover therapeutics
that prevent or delay the onset of Alzheimer's disease. Efforts at rational drug design …

Advances in genomics and proteomics have opened up new possibilities for the rapid
functional assignment and global characterization of proteins. Large-scale studies have …