Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - Signal transduction and …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Atrial fibrillation: pathogenesis, predisposing factors, and genetics

M Sagris, EP Vardas, P Theofilis… - International journal of …, 2021 - mdpi.com
Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is
linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of …

Long-term cardiovascular effects of COVID-19: emerging data relevant to the cardiovascular clinician

DL Tobler, AJ Pruzansky, S Naderi, AP Ambrosy… - Current atherosclerosis …, 2022 - Springer
Purpose of Review COVID-19 is now a global pandemic and the illness affects multiple
organ systems, including the cardiovascular system. Long-term cardiovascular …

The impact of SGLT2 inhibitors on inflammation: A systematic review and meta-analysis of studies in rodents

P Theofilis, M Sagris, E Oikonomou… - International …, 2022 - Elsevier
Background Inhibition of sodium-glucose cotransporter-2 (SGLT2) has received remarkable
attention due to the beneficial effects observed in diabetes mellitus, heart failure, and kidney …

The impact of cytokines in coronary atherosclerotic plaque: current therapeutic approaches

P Tsioufis, P Theofilis, K Tsioufis… - International Journal of …, 2022 - mdpi.com
Coronary atherosclerosis is a chronic pathological process that involves inflammation
together with endothelial dysfunction and lipoprotein dysregulation. Experimental studies …

[HTML][HTML] Role of SARS-COV-2 and ACE2 in the pathophysiology of peripheral vascular diseases

H Tanzadehpanah, E Lotfian, A Avan, S Saki… - Biomedicine & …, 2023 - Elsevier
The occurrence of a novel coronavirus known as severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2), created a serious challenge worldwide. SARS-CoV-2 has …

Telomere length: a cardiovascular biomarker and a novel therapeutic target

M Sagris, P Theofilis, AS Antonopoulos… - International Journal of …, 2022 - mdpi.com
Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly
in develo** countries. Currently, the investigation of telomeres as a potential tool for the …

Vascular alterations following COVID-19 infection: A comprehensive literature review

P Karakasis, A Nasoufidou, M Sagris, N Fragakis… - Life, 2024 - mdpi.com
SARS-CoV-2, the causative agent of the ongoing COVID-19 pandemic, has revealed a
broader impact beyond the respiratory system, predominantly affecting the vascular system …

Inflammation in coronary microvascular dysfunction

M Sagris, P Theofilis, AS Antonopoulos… - International journal of …, 2021 - mdpi.com
Chronic low-grade inflammation is involved in coronary atherosclerosis, presenting multiple
clinical manifestations ranging from asymptomatic to stable angina, acute coronary …

Diabetes mellitus and heart failure: epidemiology, pathophysiologic mechanisms, and the role of SGLT2 inhibitors

P Theofilis, E Oikonomou, K Tsioufis, D Tousoulis - Life, 2023 - mdpi.com
Diabetes mellitus (DM) and heart failure (HF) are frequently encountered afflictions that are
linked by a common pathophysiologic background. According to landmark studies, those …