The effect of size, morphology and surface properties of mesoporous silica nanoparticles on pharmacokinetic aspects and potential toxicity concerns

U Niroumand, N Firouzabadi, G Goshtasbi… - Frontiers in …, 2023 - frontiersin.org
Mesoporous silica nanoparticles (MSNs) are considered as suitable delivery vehicles
considering their unique characteristics. Various physicochemical characteristics of MSNs …

Recent advances in surface decoration of nanoparticles in drug delivery

PD Ly, KN Ly, HL Phan, HHT Nguyen… - Frontiers in …, 2024 - frontiersin.org
Nanoparticulate delivery systems have been attracting attention in pharmaceutical sciences
for enhanced drug bioavailability and targeted delivery. Specifically, these systems can …

[HTML][HTML] Current non-metal nanoparticle-based therapeutic approaches for glioblastoma treatment

AM Gawel, A Betkowska, E Gajda, M Godlewska… - Biomedicines, 2024 - mdpi.com
The increase in the variety of nano-based tools offers new possibilities to approach the
therapy of poorly treatable tumors, which includes glioblastoma multiforme (GBM; a primary …

Nanocarriers for methotrexate delivery/codelivery in the frame of cancer diagnostics and treatment: a review

M Mukhtar, AL Ezra Manicum… - Frontiers in …, 2023 - frontiersin.org
Cancer is one of the most life-threatening family of diseases that cause death worldwide. As
a highly researched and successful therapeutic agent, methotrexate (MTX) treats many solid …

[HTML][HTML] Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges

R Puttasiddaiah, N Basavegowda… - Pharmaceutics, 2025 - mdpi.com
Malignant growth is expected to surpass other significant causes of death as one of the top
reasons for dismalness and mortality worldwide. According to a World Health Organization …

Methotrexate-Loaded Surface-Modified Solid Lipid Nanoparticles Targeting Cancer Expressing COX-2 Enzyme

S Patra, J Dey, S Kar, A Chakraborty, M Tawate - Langmuir, 2024 - ACS Publications
Cancer is a major public health problem worldwide, and it is the second leading cause of
death of humans in the world. The present study has been directed toward the preparation of …

Nanostructure-reinforced multifunctional hydrogels for synergistic cancer therapy

S Yousefiasl, M Ghovvati, M Mirshafiei, F Hakimi… - Coordination Chemistry …, 2025 - Elsevier
Hydrogel-integrated nanostructures offer a novel approach to cancer therapy by combining
hydrogels' biocompatibility and tunable drug release with nanotechnology. These …

Cell-Penetrating Peptides-Mediated Therapeutic Agents Delivery into the Central Nervous System

Y Wei, H Bao, L Wang, Y Cao, Z Liu, X Zhu… - ACS Materials …, 2024 - ACS Publications
There has been a significant increase in the prevalence of central nervous system (CNS)
disorders, resulting in a considerable decrease in the overall well-being for affected …

Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases

M Ismail, J Liu, N Wang, D Zhang, C Qin, B Shi… - Biomaterials, 2025 - Elsevier
Despite the increasing global prevalence of neurological disorders, the development of
nanoparticle (NP) technologies for brain-targeted therapies confronts considerable …

Brain Targeting Nanomedicines: Pitfalls and Promise

A Kakinen, Y Jiang, TP Davis, T Teesalu… - International Journal of …, 2024 - Taylor & Francis
Brain diseases are the most devastating problem among the world's increasingly aging
population, and the number of patients with neurological diseases is expected to increase in …