Interactions between bacterial and phage communities in natural environments

A Chevallereau, BJ Pons, S van Houte… - Nature Reviews …, 2022 - nature.com
We commonly acknowledge that bacterial viruses (phages) shape the composition and
evolution of bacterial communities in nature and therefore have important roles in ecosystem …

Metabolic and biogeochemical consequences of viral infection in aquatic ecosystems

AE Zimmerman, C Howard-Varona… - Nature Reviews …, 2020 - nature.com
Ecosystems are controlled by 'bottom-up'(resources) and 'top-down'(predation) forces. Viral
infection is now recognized as a ubiquitous top-down control of microbial growth across …

Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …

Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication

E Maffei, AK Woischnig, MR Burkolter, Y Heyer… - Nature …, 2024 - nature.com
Bacteriophages are ubiquitous viral predators that have primarily been studied using fast-
growing laboratory cultures of their bacterial hosts. However, microbial life in nature is …

Phage therapy as an alternative or complementary strategy to prevent and control biofilm-related infections

DP Pires, LDR Melo, DV Boas, S Sillankorva… - Current opinion in …, 2017 - Elsevier
Highlights•Interaction of phages and biofilm cells depends on phage-host characteristics
and biofilm structure.•Biofilm features (eg matrix, cell metabolic state, resistant variants) …

Black box of phage–bacterium interactions: Exploring alternative phage infection strategies

S Mäntynen, E Laanto, HM Oksanen… - Open …, 2021 - royalsocietypublishing.org
The canonical lytic–lysogenic binary has been challenged in recent years, as more
evidence has emerged on alternative bacteriophage infection strategies. These infection …

Phage predation accelerates the spread of plasmid-encoded antibiotic resistance

C Ruan, J Ramoneda, A Kan, TJ Rudge… - Nature …, 2024 - nature.com
Phage predation is generally assumed to reduce microbial proliferation while not
contributing to the spread of antibiotic resistance. However, this assumption does not …

Understanding the complex phage-host interactions in biofilm communities

DP Pires, LDR Melo, J Azeredo - Annual Review of Virology, 2021 - annualreviews.org
Bacteriophages and bacterial biofilms are widely present in natural environments, a fact that
has accelerated the evolution of phages and their bacterial hosts in these particular niches …